Poly(D,L-lactide-co-glycolide)
Based on 1 Customer Validation
Poly(D,L-lactide-co-glycolide) is a biodegradable polymer copolymer. Poly(D,L-lactide-co-glycolide) undergoes degradation through ester bond hydrolysis into lactic acid and glycolic acid. These two products can be naturally eliminated through metabolism in the body (such as the tricarboxylic acid cycle), without the risk of long-term accumulation. Poly(D,L-lactide-co-glycolide) can be used in medical sutures, implants, and drug delivery systems.
For research use only. We do not sell to patients.
- CAS No.: 26780-50-7
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Poly(D,L-lactide-co-glycolide) forms PLGA-PEO nanoparticles, which do not exhibit significant oxidative stress induction activity and cytotoxicity towards primary rat liver cells[1].
Poly(D,L-lactide-co-glycolide) can be used to construct drug delivery systems, which can specifically deliver drugs to tumor sites through passive targeting. By surface modification (such as PEGylation) and connection with targeting ligands (such as folic acid, transferrin, RGD peptide, antibodies, etc.), its targeting ability and therapeutic effect on other types of tumors can be significantly improved[2].
Poly(D,L-lactide-co-glycolide) can be used to construct nanoparticles loaded with PLP (139-151) (HY-P0129) peptide, and integrate them into soluble polymer microneedle patches, thereby studying antigen-specific immunity in multiple sclerosis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 26780-50-7
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Appearance Solid
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Color Off-white to light brown
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SMILES
CC(C(OCC(OC)=O)=O)C.[m].[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Aranda A, et al. Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells. Toxicol In Vitro. 2013 Mar;27(2):954-63. [Content Brief]
[2]. Holgado MA, et al. Possibilities of poly(D,L-lactide-co-glycolide) in the formulation of nanomedicines against cancer. Curr Drug Targets. 2011 Jul 1;12(8):1096-111. [Content Brief]
[3]. Lima AF, et al. Poly(d,l-lactide-co-glycolide) (PLGA) Nanoparticles Loaded with Proteolipid Protein (PLP)-Exploring a New Administration Route. Polymers (Basel). 2020 Dec 21;12(12):3063. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Poly(D,L-lactide-co-glycolide) Related Classifications
HY-W723152 Related Classifications
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