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Cat. No.: HY-D1005A6

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Poloxamer 124 (L44)

(Synonyms: PEG-PPG-PEG, 2200 (Average))

Customer Review

Based on 1 Customer Validation

Poloxamer 124 L44 is a block polymer of polyoxyethylene and polyoxypropylene and a hydrophobic surfactant. Poloxamer 124 L44 causes eye irritation and exhibits oral toxicity in albino rats with an LD₅₀ of 5 g/kg. Poloxamer 124 L44 has reversible adverse effects on triglyceride and cholesterol transport in the lymphatic system of rats. Poloxamer 124 L44 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering[1][2][3].

For research use only. We do not sell to patients.

CAS No.: 9003-11-6
Molecular Weight:2200 (Average)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Poloxamer 124 (L44) Chemical Structure

CAS No.: 9003-11-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

Poloxamer 124 (L44) (Pluronic L-81) (0.17 mg/mL, 3 mL/h; intragastrically, for 1 h) significantly reduces the transport of triglycerides and cholesterol and the export of phospholipids in the lymphatic system of rats, without affecting the digestive and absorptive functions of rats (the recovery rates of lipids and cholesterol in the intestinal lumen of rats do not change significantly). This indicates that Poloxamer 124 (L44) interferes with the assembly of lipoproteins and/or the excretion of lipoproteins from mucosal cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 9003-11-6
Appearance Solid-Liquid Mixture
Molecular Weight 2200 (Average)
Color Colorless to off-white
SMILES

[Poloxamer 124 (L44)]
Synonyms

PEG-PPG-PEG, 2200 (Average)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O : ≥ 200 mg/mL

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Singh-Joy SD, et al., Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 188, 212, 215, 217, 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402, 403, and 407, poloxamer 105 benzoate, and poloxamer 182 dibenzoate as used in cosmetics. Int J Toxicol. 2008;27 Suppl 2:93-128. [Content Brief]

[2]. Li Y, et al., Ultra-high-performance liquid chromatography coupled with quadrupole time of flight mass spectrometry method for quantifying polymer poloxamer 124 and its application to pharmacokinetic study. J Sep Sci. 2021 Oct;44(20):3822-3829. [Content Brief]

[3]. Tso P, et al. Effect of hydrophobic surfactant (Pluronic L-81) on lymphatic lipid transport in the rat. Am J Physiol. 1980 Nov;239(5):G348-53. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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