Gelatins
Based on 1 Customer Validation
Gelatins is a non-toxic, non carcinogenic, biodegradable, and non irritating natural polymer derived from partial hydrolysis of collagen. Due to its strong liquid absorption and swelling ability, Gelatins has excellent hemostatic properties and can be used as a matrix material for the reduction, growth, and stability of metal nanoparticles. Gelatins can also be used for tumor cell culture and tumor therapy.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 9000-70-8
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Gelatins (6-12 %, 5 days) forms gelatin@NWF Derivatives serve as long-term storage scaffolds to promote the formation of prostate tumor cell spheroids for culturing tumor cells[3]. Gelatins (0-200 μg/mL, 24 h) can enhance cell adhesion, growth, and wound healing of HaCaT cells, and protect HaCaT cells from H2O2 induced cell damage[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human prostate cancer cell DU145
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Concentration:6-12 %
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Incubation Time:5 days
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Result:Supported more cell growth than pure non-woven fabric (NWF) scaffolds
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Cell Line:Human keratinocyte-derived (HaCaT) cells
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Concentration:0-200 μg/mL
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Incubation Time:24 h
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Result:Increased cell growth percentage in the concentration range of 25-75 μg/mL, but decreased cell growth percentage in the concentration range of 100-200 μg/mL.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Traumatic spinal cord injury Wistar rat model[1].
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Dosage:20 μg/kg Au NPs/Gelatin nanocomposite
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Administration:Intraperitoneal injection (i.p.)
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Result:Improved hind limb function, reduced cavity area, increased the number of ventral motor neurons, and demonstrated higher BBB scores and lower delayed responses in sensory tests.
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Animal Model:SD female rat femoral injury model[2].
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Dosage:A pre-weighed hemostatic sponge
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Administration:Apply to the wound
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Result:Reduced hemostasis time and blood loss.
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Animal Model:Female ICR mouse model of ectopic transplantation of mouse sarcoma cell line S180[4].
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Dosage:10 mg DOX/kg
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Administration:Intravenous injection (i.v.); once every two days; 14 days
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Result:Reduced tumor volume, prevented tumor cell spread, and lowered cardiac toxicity.
Chemical Information
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CAS No. 9000-70-8
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Appearance Solid
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Color White to yellow
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SMILES
[Gelatins]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 50 mg/mL (Need ultrasonic)
DMSO : 4.55 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL; Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[3]. Fu J, et al. Lyophilized Gelatin@non-Woven Scaffold to Promote Spheroids Formation and Enrich Cancer Stem Cell Incidence. Nanomaterials (Basel). 2022 Feb 28;12(5):808. [Content Brief]
[4]. Dong L, et al. A pH/enzyme-responsive tumor-specific delivery system for doxorubicin. Biomaterials. 2010 Aug;31(24):6309-16. [Content Brief]
[5]. Huang CY, et al. Enhancement of Cell Adhesion, Cell Growth, Wound Healing, and Oxidative Protection by Gelatins Extracted from Extrusion-Pretreated Tilapia (Oreochromis sp.) Fish Scale. Molecules. 2018 Sep 20;23(10):2406. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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