1. PROTAC
  2. PROTAC Linkers
  3. Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite

Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite 

Cat. No.: HY-W096141
Handling Instructions

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Chemical Structure

Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Chemical Structure

CAS No. : 1391728-01-0

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Description

Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

344.39

Formula

C16H29N2O4P

CAS No.
SMILES

N#CCCOP(N(C(C)C)C(C)C)OCCOCCOCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Propargyl-PEG3-1-o-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
Cat. No.:
HY-W096141
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