Propargyl-PEG4-sulfonic acid

Name: Propargyl-PEG4-sulfonic acid
Brand: MedChemExpress
SKU: HY-140047
Rating: 4.5 (0 reviews)

Cat. No.: HY-140047 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Propargyl-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-sulfonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Propargyl-PEG4-sulfonic acid 화학구조

CAS No. : 1817735-29-7

사이즈	재고	수량
250 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	견적 받기	Estimated Time of Arrival: December 31
10 g	견적 받기
50 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Propargyl-PEG4-sulfonic acid:

Propargyl-PEG4-sulfonic acid sodium In-stock

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•Related Small Molecules:

•Related Proteins:

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Propargyl-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Propargyl-PEG4-sulfonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

296.34

화학식

C₁₁H₂₀O₇S

CAS No.

1817735-29-7

Appearance

Solid

Color

White to off-white

SMILES

C#CCOCCOCCOCCOCCS(=O)(O)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

용액&용해도

In Vitro:

DMSO : 50 mg/mL (168.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3745 mL	16.8725 mL	33.7450 mL
5 mM	0.6749 mL	3.3745 mL	6.7490 mL
10 mM	0.3375 mL	1.6873 mL	3.3745 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.0%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (241 KB) HNMR (246 KB) MS (74 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3745 mL	16.8725 mL	33.7450 mL	84.3626 mL
	5 mM	0.6749 mL	3.3745 mL	6.7490 mL	16.8725 mL
	10 mM	0.3375 mL	1.6873 mL	3.3745 mL	8.4363 mL
	15 mM	0.2250 mL	1.1248 mL	2.2497 mL	5.6242 mL
	20 mM	0.1687 mL	0.8436 mL	1.6873 mL	4.2181 mL
	25 mM	0.1350 mL	0.6749 mL	1.3498 mL	3.3745 mL
	30 mM	0.1125 mL	0.5624 mL	1.1248 mL	2.8121 mL
	40 mM	0.0844 mL	0.4218 mL	0.8436 mL	2.1091 mL
	50 mM	0.0675 mL	0.3375 mL	0.6749 mL	1.6873 mL
	60 mM	0.0562 mL	0.2812 mL	0.5624 mL	1.4060 mL
	80 mM	0.0422 mL	0.2109 mL	0.4218 mL	1.0545 mL
	100 mM	0.0337 mL	0.1687 mL	0.3375 mL	0.8436 mL