1. Immunology/Inflammation
  2. CD73
  3. PSB-12379 disodium

PSB-12379 disodium 

Cat. No.: HY-100747A
Handling Instructions

PSB-12379 disodium, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

For research use only. We do not sell to patients.

PSB-12379 disodium Chemical Structure

PSB-12379 disodium Chemical Structure

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PSB-12379 disodium, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human)[1][2].

IC50 & Target

Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)[1].

In Vivo

Metabolism: Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight





Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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