2. Immunology/Inflammation
  3. CD73
  4. PSB-12379

PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

For research use only. We do not sell to patients.

PSB-12379 Chemical Structure

PSB-12379 Chemical Structure

CAS No. : 1802226-78-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 231 In-stock
Solution
10 mM * 1 mL in Water USD 231 In-stock
Solid
5 mg USD 204 In-stock
10 mg USD 312 In-stock
25 mg USD 672 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of PSB-12379:

PSB-12379 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human)[1][2].

IC50 & Target

Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)[1]
In Vitro

Metabolism: Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PSB-12379 Related Antibodies
Molecular Weight

515.35

Formula

C18H23N5O9P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O)CP(OC[C@H]1O[C@@H](N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C32)[C@H](O)[C@@H]1O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (242.55 mM; Need ultrasonic)

DMSO : ≥ 5 mg/mL (9.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9404 mL 9.7021 mL 19.4043 mL
5 mM 0.3881 mL 1.9404 mL 3.8809 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (194.04 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.54%

COA (258 KB) HNMR (188 KB) LCMS (652 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.9404 mL 9.7021 mL 19.4043 mL 48.5107 mL
5 mM 0.3881 mL 1.9404 mL 3.8809 mL 9.7021 mL
H2O 10 mM 0.1940 mL 0.9702 mL 1.9404 mL 4.8511 mL
15 mM 0.1294 mL 0.6468 mL 1.2936 mL 3.2340 mL
20 mM 0.0970 mL 0.4851 mL 0.9702 mL 2.4255 mL
25 mM 0.0776 mL 0.3881 mL 0.7762 mL 1.9404 mL
30 mM 0.0647 mL 0.3234 mL 0.6468 mL 1.6170 mL
40 mM 0.0485 mL 0.2426 mL 0.4851 mL 1.2128 mL
50 mM 0.0388 mL 0.1940 mL 0.3881 mL 0.9702 mL
60 mM 0.0323 mL 0.1617 mL 0.3234 mL 0.8085 mL
80 mM 0.0243 mL 0.1213 mL 0.2426 mL 0.6064 mL
100 mM 0.0194 mL 0.0970 mL 0.1940 mL 0.4851 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PSB-12379 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB-123791802226-78-3PSB12379PSB 12379CD73ecto-5′-nucleotidase, NT5EInhibitorinhibitorinhibit

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