1. Immunology/Inflammation
  2. CD73
  3. PSB-12379

PSB-12379 

Cat. No.: HY-100747 Purity: 99.99%
Handling Instructions

PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

For research use only. We do not sell to patients.

PSB-12379 Chemical Structure

PSB-12379 Chemical Structure

CAS No. : 1802226-78-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in Water USD 231 In-stock
Estimated Time of Arrival: December 31
5 mg USD 204 In-stock
Estimated Time of Arrival: December 31
10 mg USD 312 In-stock
Estimated Time of Arrival: December 31
25 mg USD 672 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human)[1][2].

IC50 & Target

Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)[1]

In Vitro

Metabolism: Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

515.35

Formula

C₁₈H₂₃N₅O₉P₂

CAS No.

1802226-78-3

SMILES

O[[email protected]@H]([[email protected]]1O)[[email protected]@H](COP(CP(O)(O)=O)(O)=O)O[[email protected]]1N(C=N2)C3=C2C(NCC4=CC=CC=C4)=NC=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 7.14 mg/mL (13.85 mM; Need ultrasonic)

DMSO : ≥ 5 mg/mL (9.70 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9404 mL 9.7021 mL 19.4043 mL
5 mM 0.3881 mL 1.9404 mL 3.8809 mL
10 mM 0.1940 mL 0.9702 mL 1.9404 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.99%

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Keywords:

PSB-12379PSB12379PSB 12379CD73ecto-5′-nucleotidase, NT5EInhibitorinhibitorinhibit

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PSB-12379
Cat. No.:
HY-100747
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