PSB-12379
Based on 5 publication(s) in Google Scholar
PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.96%
- CAS No.: 1802226-78-3
- 화학식: C18H23N5O9P2
- 분자량:515.35
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
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Publications Citing Use of MedChemExpress (MCE) PSB-12379
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Biological Activity
Ki: 9.03 nM (rat), 2.21 nM (human) (Ecto-5’-Nucleotidase)[1]
Metabolism: Only a small percentage (<23%) of PSB-12379 (10g) is metabolized under the applied conditions, while >77% of the compounds are recovered unchanged after a long incubation for 8 h. PSB-12379 (10g) is somewhat less stable, and 56% are metabolized within 8 h. Hydrolytic cleavage of the glycosidic bond, which is a typical phase I reaction of nucleosides and nucleotides, was observed as the main reaction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1802226-78-3
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Appearance Solid
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분자량 515.35
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화학식 C18H23N5O9P2
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Color White to off-white
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SMILES
O=P(O)(O)CP(OC[C@H]1O[C@@H](N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C32)[C@H](O)[C@@H]1O)(O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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Front Bioeng Biotechnol
CD73-Positive Small Extracellular Vesicles Derived From Umbilical Cord Mesenchymal Stem Cells Promote the Proliferation and Migration of Pediatric Urethral Smooth Muscle Cells Through Adenosine Pathway. [Abstract]2022 Apr 27;10:895998. PMID: 35573239 -
Cancers (Basel)
Adenosine 2A Receptor Activation Amplifies Ibrutinib Antiplatelet Effect; Implications in Chronic Lymphocytic Leukemia. [Abstract]2022 Nov 23;14(23):5750. PMID: 36497231 -
bioRxiv
Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation. [Abstract]2026 Apr 1:2026.03.31.715684. PMID: 41959015 -
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용액&용해도
H2O : 125 mg/mL (242.55 mM; Need ultrasonic)
DMSO : ≥ 5 mg/mL (9.70 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (194.04 mM); Clear solution; Need ultrasonic
순도&문서
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Data Sheet (281 KB)
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SDS (583 KB)
- English - EN (583 KB)
- Français - FR (583 KB)
- Deutsch - DE (583 KB)
- Norwegian - NO (583 KB)
- Español - ES (583 KB)
- Swedish - SV (583 KB)
- Italian - IT (583 KB)
- Korean - KR (583 KB)
- Portuguese - PT (583 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.9404 mL | 9.7021 mL | 19.4043 mL | 48.5107 mL |
| 5 mM | 0.3881 mL | 1.9404 mL | 3.8809 mL | 9.7021 mL | |
| H2O | 10 mM | 0.1940 mL | 0.9702 mL | 1.9404 mL | 4.8511 mL |
| 15 mM | 0.1294 mL | 0.6468 mL | 1.2936 mL | 3.2340 mL | |
| 20 mM | 0.0970 mL | 0.4851 mL | 0.9702 mL | 2.4255 mL | |
| 25 mM | 0.0776 mL | 0.3881 mL | 0.7762 mL | 1.9404 mL | |
| 30 mM | 0.0647 mL | 0.3234 mL | 0.6468 mL | 1.6170 mL | |
| 40 mM | 0.0485 mL | 0.2426 mL | 0.4851 mL | 1.2128 mL | |
| 50 mM | 0.0388 mL | 0.1940 mL | 0.3881 mL | 0.9702 mL | |
| 60 mM | 0.0323 mL | 0.1617 mL | 0.3234 mL | 0.8085 mL | |
| 80 mM | 0.0243 mL | 0.1213 mL | 0.2426 mL | 0.6064 mL | |
| 100 mM | 0.0194 mL | 0.0970 mL | 0.1940 mL | 0.4851 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PSB-12379 Related Classifications
HY-100747 Related Classifications
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