Annexin A8/ANXA8 Protein, Human

Annexin A8 Protein, Human is an approximately 36.0 kDa protein produced by our E.coli expression system^[1].

The Annexins comprise a family of proteins that are involved in many aspects of cellular membrane dynamics and the regulation of membrane-associated proteins.
Annexin A8 contains 4 annexin repeats separated by linking sequences of variable lengths. A pair of annexin repeats may form one binding site for calcium and phospholipid. Annexin A8 is expressed in many types of malignant tumors, such as acute promyelocytic leukemia, cholangiocarcinoma, breast cancer, and pancreatic cancer^[1].

Human

E. coli

Tag Free

P13928-1 (M1-P327)

653145  [NCBI]

Full Length of Isoform-1

MAWWKSWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPGLALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP

Approximately 36.0 kDa

≥ 80%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Rui Gou, et al. Annexin A8 can serve as potential prognostic biomarker and therapeutic target for ovarian cancer: based on the comprehensive analysis of Annexins. J Transl Med. 2019 Sep 2;17(1):275  [Content Brief]

  [2]. Nicole Heitzig, et al. Annexin A8 promotes VEGF-A driven endothelial cell sprouting. Cell Adh Migr. 2017 May 4;11(3):275-287.  [Content Brief]