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ANXA8 - annexin A8 Gene

Also Known as ANX8; CH17-360D5.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 653145

About ANXA8

Cytogenetic location: 10q11.22 Genomic coordinates (GRCh38): 10:47,467,993-47,991,796 (from NCBI)

This gene has 8 transcripts (splice variants), 336 orthologues and 12 paralogues. Biased expression in skin (RPKM 96.8), esophagus (RPKM 57.8) and 3 other tissues.

Summary

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]

ANXA8 Products (3)

mRNA	Protein	Name
NM_001040084.3	NP_001035173.1	annexin A8 isoform 2
NM_001271702.2	NP_001258631.1	annexin A8 isoform 1
NM_001271703.2	NP_001258632.1	annexin A8 isoform 3

ANXA8 Protein Structure

Annexin

0
100
200
300
327 a.a.

Protein Preferred Names	Protein Names
annexin A8	VAC-beta

ANXA8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ANXA8	P13928	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	ANXA8	P13928	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	ANXA8	P13928	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	ANXA8	P13928	ACTA1	Homo sapiens	P68133	Anti Tag CoIP	28514442
Intra	ANXA8	P13928	ACTA1	Homo sapiens	P68133	Anti Tag CoIP	33961781
Intra	ANXA8	P13928	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	ANXA8	P13928	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	ANXA8	P13928	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	ANXA8	P13928	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	ANXA8	P13928	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	ANXA8	P13928	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	ANXA8	P13928	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	ANXA8	P13928	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ANXA8	P13928	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ANXA8	P13928	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	ANXA8	P13928	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	ANXA8	P13928	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	ANXA8	P13928	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	ANXA8	P13928	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	ANXA8	P13928	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	ANXA8	P13928	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	ANXA8	P13928	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	ANXA8	P13928	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANXA8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7520	Annexin A8/ANXA8 Protein, Human	P13928-1 (M1-P327)	≥ 80%, as determined by reducing SDS-PAGE.
HY-P75505	Annexin A8/ANXA8 Protein, Human (His)	P13928-1 (M1-P327)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Metagonimiasis	Trematode Infections Infection By Metagonimus Yokogawai Metagonimus Yokogawai Infection
Heterophyiasis	Heterophyes Infectious Disease
Acute Laryngopharyngitis	Pharyngolaryngitis Laryngopharyngitis Hypopharyngitis
Trachea Leiomyoma	Tracheal Neoplasms Leiomyoma Of The Trachea Tracheal Neoplasm Tracheal Leiomyoma
Aortic Aneurysm, Familial Abdominal, 1	Abdominal Aortic Aneurysm Aortic Aneurysm, Familial Abdominal 1 Aneurysm, Abdominal Aortic AAA Aortic Aneurysm, Abdominal AAA1 Aortic Aneurysm, Familial Abdominal Aortic Aneurysm Abdominal Abdominal Aortic Aneurysms Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture Abdomen Aneurysm Abdominal Aorta Aneurysm Aneurysm Of Abdominal Aorta Aortic Abdomen Aneurysm Aaa - [Abdominal Aortic Aneurysm] Abdominal Aneurysm Abdominal Aorta Aneurysm Rupture Abdominal Aorta Aneurysm Ruptured Abdominal Aortic Aneurysm Which Has Ruptured Ruptured Aaa Abdomen Aorta Aneurysm Ruptured Abdomen Aorta Rupture Abdomen Aortic Aneurysm Rupture Abdomen Aneurysm Rupture Abdomen Aortic Aneurysm Ruptured Abdomen Aortic Rupture Abdominal Aorta Rupture Abdominal Aortic Rupture Rupture Abdomen Aorta Aneurysm Rupture Abdominal Aortic Aneurysm Ruptured Abdomen Aneurysm Ruptured Abdomen Aorta Ruptured Abdomen Aortic Ruptured Abdominal Aneurysm Ruptured Abdominal Aorta Ruptured Abdominal Aortic Ruptured Aorta Abdominalis Aneurysm False Abdomen Aorta Aneurysm Ruptured False Abdominal Aortic Aneurysm Ruptured False Abdominal Aorta Aneurysm Ruptured False Abdomen Aortic Aneurysm Ruptured

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS25659	Anxa8 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ANXA8	MGD	MGI:1201374
Rattus norvegicus	ANXA8	RGD	RGD:1307719