Annexin A8/ANXA8 Protein, Human (His)
Based on 1 publication(s) in Google Scholar
The annexin A8 (ANXA8) protein acts as an anticoagulant, indirectly inhibiting the thromboplastin-specific complex in the coagulation cascade. Its regulatory role underscores its importance in regulating key components of the coagulation pathway, highlighting its potential to influence the delicate balance between pro- and anticoagulant factors. Annexin A8/ANXA8 Protein, Human (His) is the recombinant human-derived Annexin A8/ANXA8 protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The annexin A8 (ANXA8) protein acts as an anticoagulant, indirectly inhibiting the thromboplastin-specific complex in the coagulation cascade. Its regulatory role underscores its importance in regulating key components of the coagulation pathway, highlighting its potential to influence the delicate balance between pro- and anticoagulant factors. Annexin A8/ANXA8 Protein, Human (His) is the recombinant human-derived Annexin A8/ANXA8 protein, expressed by E. coli , with N-6*His labeled tag.
Background
Annexin A8 (ANXA8) protein functions as an anticoagulant, operating as an indirect inhibitor of the thromboplastin-specific complex within the blood coagulation cascade. Its regulatory role in modulating the thromboplastin-specific complex emphasizes its significance in influencing key components of the coagulation pathway, suggesting its potential contribution to the delicate balance between procoagulant and anticoagulant factors in blood clotting processes. ANXA8's ability to intervene in thromboplastin-related interactions underscores its importance as a modulator in the intricate network of regulatory mechanisms that govern blood coagulation, shedding light on its potential therapeutic implications in managing coagulation disorders.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Publications (1)
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Journal Impact Factor
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Most Recent
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Research (Wash D C)
Targeting the ANXA8-SP1-PPA1 Axis to Modulate TCA Cycle and Matrix Deposition in Diffuse-Type Gastric Cancer. [Abstract]2025 Aug 25:8:0838. PMID: 40862051
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
P13928-1 (M1-P327)
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Molecular Construction
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N-term
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6*His
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ANXA8 (M1-P327)
Accession # P13928-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
ANXA8; Annexin-8; Prev. ANX8; CH17-360D5.2; Vascular Anticoagulant-Beta; Annexin; Annexin VIII; Annexin A8; VAC-Beta
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AA Sequence
MAWWKSWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPGLALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP
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Molecular Weight
Approximately 35 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 50 mM Tris-HCl, 300 mM NaCl, pH 7.4.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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