Annexin A8/ANXA8 Protein, Human
Annexin A8 Protein, Human is an approximately 36.0 kDa protein produced by our E.coli expression system.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Annexin A8 Protein, Human is an approximately 36.0 kDa protein produced by our E.coli expression system[1].
The Annexins comprise a family of proteins that are involved in many aspects of cellular membrane dynamics and the regulation of membrane-associated proteins.Annexin A8 contains 4 annexin repeats separated by linking sequences of variable lengths. A pair of annexin repeats may form one binding site for calcium and phospholipid. Annexin A8 is expressed in many types of malignant tumors, such as acute promyelocytic leukemia, cholangiocarcinoma, breast cancer, and pancreatic cancer[1].
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
P13928-1 (M1-P327)
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Molecular Construction
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N-term
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ANXA8 (M1-P327)
Accession # P13928-1 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
ANXA8; Annexin-8; Prev. ANX8; CH17-360D5.2; Vascular Anticoagulant-Beta; Annexin; Annexin VIII; Annexin A8; VAC-Beta
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AA Sequence
MAWWKSWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPGLALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSDP
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Predicted Molecular Mass
36.9 kDa
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Molecular Weight
Approximately 36 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
References
[1]. Rui Gou, et al. Annexin A8 can serve as potential prognostic biomarker and therapeutic target for ovarian cancer: based on the comprehensive analysis of Annexins. J Transl Med. 2019 Sep 2;17(1):275 [Content Brief]
[2]. Nicole Heitzig, et al. Annexin A8 promotes VEGF-A driven endothelial cell sprouting. Cell Adh Migr. 2017 May 4;11(3):275-287. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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