Artemin Protein, Mouse (HEK293, Fc)

Artemin Protein, a ligand for GFR-alpha-3-RET and GFR-alpha-1-RET receptor complexes, is vital for the survival of sensory, sympathetic, and dopaminergic neurons. It strongly attracts gut hematopoietic cells, promoting Peyer's patch-like structure formation in the gut-associated lymphoid tissue. Existing in a homodimeric form linked by disulfide bonds, Artemin binds to the RET receptor. Artemin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Artemin protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Artemin Protein, Mouse (HEK293, Fc) is 113 a.a., with molecular weight of ~40.6 kDa.

Artemin protein functions as a ligand for the GFR-alpha-3-RET receptor complex and can also activate the GFR-alpha-1-RET receptor complex. It plays a vital role in supporting the survival of sensory and sympathetic peripheral neurons in culture and additionally supports the survival of dopaminergic neurons in the ventral mid-brain. Acting as a strong attractant for gut hematopoietic cells, Artemin promotes the formation of Peyer's patch-like structures, which are integral components of the gut-associated lymphoid tissue. The protein exists in a homodimeric form, linked by disulfide bonds, and binds to the RET receptor.

Mouse

HEK293

N-hFc

Q9Z0L2 (A112-G224)

11876  [NCBI]

Approximately 40.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.