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  3. Butyrophilins
  4. BTN2A2
  5. BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi)

BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi)

Cat. No.: HY-P72344
Handling Instructions

BTN2A2 protein inhibits CD4 and CD8 T-cell proliferation activated by anti-CD3 antibodies. It regulates T-cell metabolism, suppressing IL2 and IFNG cytokine secretion. BTN2A2 plays a pivotal role in immune response modulation, maintaining immune homeostasis by limiting T-cell activation and effector functions. BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived BTN2A2 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 205 a.a., with molecular weight of 55-80 kDa.

For research use only. We do not sell to patients.

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Description

BTN2A2 protein inhibits CD4 and CD8 T-cell proliferation activated by anti-CD3 antibodies. It regulates T-cell metabolism, suppressing IL2 and IFNG cytokine secretion. BTN2A2 plays a pivotal role in immune response modulation, maintaining immune homeostasis by limiting T-cell activation and effector functions. BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived BTN2A2 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 205 a.a., with molecular weight of 55-80 kDa.

Background

BTN2A2 protein functions as an inhibitor, impeding the proliferation of both CD4 and CD8 T-cells that are activated by anti-CD3 antibodies. Additionally, it exerts regulatory control over T-cell metabolism and suppresses the secretion of the cytokines IL2 and IFNG. This inhibition reflects BTN2A2's pivotal role in modulating immune responses and maintaining immune homeostasis by limiting the activation and effector functions of T-cells.

Species

Human

Source

HEK293

Tag

C-Avi;C-hFc

Accession

Q8WVV5 (Q33-V237)

Gene ID
Molecular Construction
N-term
BTN2A2 (Q33-V237)
Accession # Q8WVV5
hFc-Avi
C-term
Synonyms
Butyrophilin subfamily 2 member A2; BTN2A2
AA Sequence

QFTVVGPANPILAMVGENTTLRCHLSPEKNAEDMEVRWFRSQFSPAVFVYKGGRERTEEQMEEYRGRITFVSKDINRGSVALVIHNVTAQENGIYRCYFQEGRSYDEAILRLVVAGLGSKPLIEIKAQEDGSIWLECISGGWYPEPLTVWRDPYGEVVPALKEVSIADADGLFMVTTAVIIRDKYVRNVSCSVNNTLLGQEKETV

Molecular Weight

55-80 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi)
Cat. No.:
HY-P72344
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