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BTN2A2 - butyrophilin subfamily 2 member A2 Gene

Also Known as BTF2; BT2.2; BTN2.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10385

About BTN2A2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,383,108-26,394,874 (from NCBI)

This gene has 16 transcripts (splice variants), 110 orthologues and 15 paralogues. Broad expression in lymph node (RPKM 8.9), appendix (RPKM 6.5) and 24 other tissues.

Summary

Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

BTN2A2 Products (6)

mRNA	Protein	Name
NM_001197237.2	NP_001184166.1	butyrophilin subfamily 2 member A2 isoform a precursor
NM_001197238.2	NP_001184167.1	butyrophilin subfamily 2 member A2 isoform c precursor
NM_001197239.2	NP_001184168.1	butyrophilin subfamily 2 member A2 isoform d precursor
NM_001197240.2	NP_001184169.1	butyrophilin subfamily 2 member A2 isoform e precursor
NM_006995.5	NP_008926.2	butyrophilin subfamily 2 member A2 isoform a precursor
NM_181531.3	NP_853509.1	butyrophilin subfamily 2 member A2 isoform b precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTN2A2 Protein Structure

V-set

C2-set_2

PRY

SPRY

0
100
200
300
400
500
523 a.a.

Protein Preferred Names	Protein Names
butyrophilin subfamily 2 member A2	butyrophilin 2

BTN2A2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BTN2A2	Q8WVV5	MRM3	Homo sapiens	Q9HC36	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	MRM3	Homo sapiens	Q9HC36	Validated Y2H	32296183
Intra	BTN2A2	Q8WVV5	MRM3	Homo sapiens	Q9HC36	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	BTN2A2	Q8WVV5	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	BTN2A2	Q8WVV5	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	GPRC5D	Homo sapiens	Q9NZD1	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	GPRC5D	Homo sapiens	Q9NZD1	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	GPRC5D	Homo sapiens	Q9NZD1	Validated Y2H	32296183
Intra	BTN2A2	Q8WVV5	SLC30A4	Homo sapiens	O14863	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	SLC30A4	Homo sapiens	O14863	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	SPNS3	Homo sapiens	Q6ZMD2-2	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	SPNS3	Homo sapiens	Q6ZMD2-2	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	BTN2A2	Q8WVV5	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	SLC14A1	Homo sapiens	Q13336-2	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	SLC14A1	Homo sapiens	Q13336-2	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	SEC11C	Homo sapiens	Q9BY50	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	SEC11C	Homo sapiens	Q9BY50	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	SEC11C	Homo sapiens	Q9BY50	Validated Y2H	32296183
Intra	BTN2A2	Q8WVV5	PSMA3	Homo sapiens	P25788	Y2H Prey Pooling	25416956
Intra	BTN2A2	Q8WVV5	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	BTN2A2	Q8WVV5	SLC1A3	Homo sapiens	P43003	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	SLC1A3	Homo sapiens	P43003	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	GJB3	Homo sapiens	O75712	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	GJB3	Homo sapiens	O75712	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	HSD3B7	Homo sapiens	Q9H2F3	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	BTN2A2	Q8WVV5	HSD3B7	Homo sapiens	Q9H2F3	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	EMP1	Homo sapiens	P54849	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	SYT1	Homo sapiens	P21579	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	SYT1	Homo sapiens	P21579	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	PEX12	Homo sapiens	O00623	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	BTN2A2	Q8WVV5	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	FATE1	Homo sapiens	Q969F0	Validated Y2H	25416956
Intra	BTN2A2	Q8WVV5	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956
Intra	BTN2A2	Q8WVV5	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956
Intra	BTN2A2	Q8WVV5	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	BTN2A2	Q8WVV5	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	BTN2A2	Q8WVV5	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	BTN2A2	Q8WVV5	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	BTN2A2	Q8WVV5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BTN2A2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7682	BTN2A2 Protein, Human (HEK293, Fc)	Q8WVV5 (Q33-V237)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72344	BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q8WVV5 (Q33-V237)	≥ 95%, as determined by reducing SDS-PAGE.

BTN2A2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84690	BTN2A2 Antibody (YA4387)	IHC-P, FC, ELISA	Human
HY-P84690A	BTN2A2 Antibody (YA4387)(PBS only)	IHC-P, FC, ELISA	Human
HY-P84691	BTN2A2 Antibody (YA4388)	WB, ICC/IF, FC, ELISA	Human
HY-P84691A	BTN2A2 Antibody (YA4388)(PBS only)	WB, ICC/IF, FC, ELISA	Human

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01672	BTN2A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18417	Btn2a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24898	Btn2a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BTN2A2	MGD	MGI:3606486
Rattus norvegicus	BTN2A2	RGD	RGD:1306973
Others	BTN2A2	NCBI