CADM4/IGSF4C Protein, Mouse (HEK293, His)

CADM4/IGSF4C Protein, vital for cell-cell adhesion, has calcium- and magnesium-independent activity. Its adhesive role suggests a function in tissue integrity. Additionally, it may act as a tumor suppressor, inhibiting cellular proliferation and tumorigenesis. As a monomer and homodimer, CADM4/IGSF4C Protein dynamically interacts, coordinating adhesion and potential tumor suppression. CADM4/IGSF4C Protein, Mouse (HEK293, His) is the recombinant mouse-derived CADM4/IGSF4C protein, expressed by HEK293 , with C-His labeled tag.

CADM4/IGSF4C Protein plays a crucial role in cell-cell adhesion, exhibiting calcium- and magnesium-independent activity. Its involvement in mediating adhesive interactions between cells suggests a potential role in maintaining tissue integrity. Beyond its adhesive functions, CADM4/IGSF4C Protein may possess tumor-suppressor activity, implicating its potential significance in regulating cellular proliferation and inhibiting tumorigenesis. As a monomer and homodimer, CADM4/IGSF4C Protein likely participates in dynamic cellular interactions, contributing to the coordination of various physiological processes related to adhesion and potential tumor suppression.

Measured by its ability to inhibit the proliferation of A549 cells. The ED₅₀ for this effect is 0.9491 μg/mL, corresponding to a specific activity is 1.054×10³ units/mg.

Mouse

HEK293

C-6*His

Q8R464 (P21-A324)

260299  [NCBI]

Partial

PGTGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAVLRWYRDRKELKGVSSGQENGKVWSVASTVRFRVDRKDDGGIVICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEAANKHGHARALYVLVVYDPGAVVEAQTSVPYA

Approximately 48-70 kDa due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.