CLEC9A Protein, Human (Biotinylated, HEK293, Fc)

The CLEC9A Protein, expressed on a specific subset of myeloid cells, efficiently uptakes and processes material from deceased cells. It recognizes filamentous actin, especially with actin-binding domains like spectrin, when cell membranes are compromised. This facilitates Syk-dependent cross-presentation of antigens from dead cells. CLEC9A functions as a homodimer, highlighting its role in specialized endocytic processes of myeloid cells. CLEC9A Protein, Human (Biotinylated, HEK293, Fc) is the recombinant human-derived CLEC9A protein, expressed by HEK293, with N-hFc labeled tag.

CLEC9A Protein operates as an endocytic receptor uniquely expressed on a specific subset of myeloid cells, designed for the efficient uptake and processing of material derived from deceased cells. This receptor exhibits a distinct recognition capability for the filamentous form of actin, particularly in conjunction with specific actin-binding domains found in cytoskeletal proteins like spectrin. This recognition occurs when cell membranes are compromised, facilitating the cross-presentation of antigens associated with dead cells in a Syk-dependent manner. Notably, CLEC9A functions as a homodimer, emphasizing its role in the specialized endocytic processes performed by this subset of myeloid cells.

Human

HEK293

N-hFc

Q6UXN8 (K57-V241)

283420

Extracellular Domain

Biotin

KLLQVSTIAMQQQEKLIQQERALLNFTEWKRSCALQMKYCQAFMQNSLSSAHNSSPCPNNWIQNRESCYYVSEIWSIWHTSQENCLKEGSTLLQIESKEEMDFITGSLRKIKGSYDYWVGLSQDGHSGRWLWQDGSSPSPGLLPAERSQSANQVCGYVKSNSLLSSNCSTWKYFICEKYALRSSV

Approximately 55-70 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.