CNTN6/Contactin-6 Protein, Human (HEK293, Fc)

The Contactin-6 (CNTN6) protein is a key player in nervous system development, promoting critical cell surface interactions. It actively participates in oligodendrocyte generation by acting as a ligand for NOTCH1. CNTN6/Contactin-6 Protein, Human (HEK293, Fc) is the recombinant human-derived CNTN6/Contactin-6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CNTN6/Contactin-6 Protein, Human (HEK293, Fc) is 999 a.a., with molecular weight of ~135.3 KDa.

Contactin-6 (CNTN6) is a crucial player in nervous system development, where contactins mediate cell surface interactions. CNTN6 participates in the generation of oligodendrocytes by serving as a ligand for NOTCH1. Its association with NOTCH1 leads to the activation of NOTCH1 through the release of the notch intracellular domain (NICD), facilitating its translocation to the nucleus. This involvement in NOTCH1 signaling underscores CNTN6's role in regulating cellular processes associated with oligodendrocyte development. Moreover, CNTN6 has been implicated in motor coordination (By similarity), suggesting its potential contribution to neural circuits governing motor function. The interaction with PTPRG further emphasizes the complex regulatory network in which CNTN6 participates during nervous system development.

Human

HEK293

C-hFc

Q9UQ52 (D20-S999)

27255  [NCBI]

Approximately 135.3 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.