CPA2 Protein, Mouse (HEK293, His)

CPA2 Protein is A member of the carboxypeptidase family that encodes zinc metalloproteinases and is expressed by pancreatic exocrine cells. CPA2 Protein acts on aromatic C-terminal residues and plays an important role in the process of degrading food to form amino acids. CPA2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CPA2 protein, expressed by HEK293 , with C-6*His labeled tag.

Carboxypeptidase A2 (CPA2) is A member of the carboxypeptidase family that encodes zinc metalloproteinases. The encoded preproprotein is treated with proteolysis to remove the N-terminal activating peptide and produce a functional enzyme. At present, three different forms of human pancreatic procarboxypeptidase A have been isolated. A1 and A2 are monomer proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues. Substrate Inhibition Inhibition of aromatic n-acyldipeptide substrates and their ester analogs Apparent CPA2 is expressed by pancreatic exocrine cells, which secrete this enzyme during digestion. This gene is located in the carboxypeptidase gene cluster on chromosome 6. CPA2 is important in the process of degrading food proteins leading to the formation of amino acids. CPA2 also plays a role in the renin-angiotensin system^[1][2][3].

Mouse

HEK293

C-6*His

Q504N0 (Q17-Y417)

232680  [NCBI]

Full Length of Mature Protein

QETFVGDQVLEVIPNDEEQIKTLLQLEAEEHLELDFWKSPSVPRQTVHVRVPFASIQDVKVFLESQGITYSIMIEDVQVLLDQEREEMLFNQQRERGTNFNFGAYHTLEEIYQEMDNLVAENPGLVSKVNIGSSFENRPMNVLKFSTGGDKPAIWLDAGIHAREWVTQATALWTANKIASDYGTDPAITSLLNTLDVFLLPVTNPDGYVFSQTSNRMWRKTRSKRSGSFCVGVDPNRNWDANFGGPGASSNPCSDSYHGPSPNSEVEVKSIVDFIKSHGKVKAFITLHSYSQLLMFPYGYKCAKPDDFNELDEVAQRAAQSLKRLHGTSYKVGPICSVIYQASGGSIDWAYDLGIKYSFAFELRDTGYYGFLLPAKQILPTAEETWLGLKTIMEHVRDHPY

Approximately 41-50 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. /biology-dictionary/a2780-cell.html  [Content Brief]