Cystatin SA/CST2 Protein, Human (HEK293, His)

Cystatin SA/CST2 Protein, Human (HEK 293, His) is a recombinant cystatin SA/CST2 protein with His tag. Human salivary cystatin SA exhibits antimicrobial effect against Aggregatibacter actinomycetemcomitans^[1].

The complete nucleotide sequence of the gene that codes for the precursor form of the neutral salivary protein, cystatin SN, was determined. The gene, which we name CST1, contains three exons and two intervening sequences. The expected CAT and ATA boxes are present in the 5'-flanking region of the gene. Partial nucleotide sequence determination of a second gene revealed that it codes for the precursor form of the acidic salivary protein, cystatin SA. This gene, which we name CST2, has the same gene organization as CST1^[2].

Human

HEK293

C-6*His

P09228 (W21-A141)

1470  [NCBI]

Full Length of Mature Protein

WSPQEEDRIIEGGIYDADLNDERVQRALHFVISEYNKATEDEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFQIYEVPWEDRMSLVNSRCQEA

Approximately 16 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. Ganeshnarayan K, et al Human salivary cystatin SA exhibits antimicrobial effect against Aggregatibacter actinomycetemcomitans. J Periodontal Res. 2012;47(5):661-673.  [Content Brief]

  [2]. Saitoh E, et al. Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family. Gene. 1987;61(3):329-338.  [Content Brief]