CST2 - cystatin SA Gene

Homo sapiens

Gene ID: 1470 | Gene type: protein coding

About CST2

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,823,769-23,826,729 (from NCBI)

This gene has 1 transcript (splice variant), 99 orthologues and 11 paralogues. Restricted expression toward salivary gland (RPKM 1475.8).

Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]

CST2 Products(1)

mRNA	Protein	Name
NM_001322.3	NP_001313.1	cystatin-SA precursor

Protein Preferred Names

Protein Names

cystatin-SA

cystatin 2

Recombinant CST2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7891	Cystatin SA/CST2 Protein, Human (HEK293, His)	P09228 (W21-A141)	≥95%