DTX3 Protein, Human

The DTX3 protein is a multifunctional regulator of Notch signaling that regulates intercellular communication and cell fate decisions. Its effects are context-dependent, exhibiting positive and negative regulation depending on the developmental and cellular environment. DTX3 Protein, Human is the recombinant human-derived DTX3 protein, expressed by E. coli , with tag free.

DTX3 emerges as a versatile regulator within the intricate landscape of Notch signaling, a pivotal pathway orchestrating cell-cell communications and governing diverse cell-fate determinations. Its role appears context-dependent, exerting both positive and negative modulation on Notch signaling, contingent upon the specific developmental and cellular milieu. The functional versatility of DTX3 extends to its capacity as an ubiquitin ligase protein in vitro, suggesting its potential involvement in ubiquitin-mediated regulatory mechanisms within the Notch pathway. This dual functionality underscores the complexity and adaptability of DTX3 in fine-tuning Notch signaling dynamics, contributing to the intricate regulatory network governing cellular fate decisions.

Human

E. coli

Tag Free

Q8N9I9 (S2-D347)

196403

Partial

SFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. /biology-dictionary/rerf-lc-ms-cell.html