EIF3M Protein, Human (His-SUMO)

EIF3M protein serves as an integral component of the eukaryotic translation initiation factor 3 (eIF-3) complex, crucial for orchestrating multiple steps in the initiation of protein synthesis. This complex associates with the 40S ribosome, facilitating the recruitment of essential factors such as eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5 to form the 43S pre-initiation complex (43S PIC). EIF-3M actively promotes mRNA recruitment to the 43S PIC, scanning of the mRNA for AUG recognition, and subsequent prevention of premature joining of the 40S and 60S ribosomal subunits prior to initiation. Furthermore, the EIF-3 complex plays a pivotal role in the disassembly and recycling of post-termination ribosomal complexes. Remarkably, EIF3M is instrumental in the translation initiation of specific mRNAs associated with cell proliferation, encompassing processes like cell cycling, differentiation, and apoptosis. It employs distinct modes of RNA stem-loop binding to exert either translational activation or repression. Additionally, in the context of microbial infection, EIF3M may facilitate virus entry during infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).