EIF3M - eukaryotic translation initiation factor 3 subunit M Gene

Also Known as B5; GA17; PCID1; TANGO7; hfl-B5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10480

About EIF3M

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:32,583,831-32,606,264 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 68.3), thyroid (RPKM 54.3) and 25 other tissues.

Summary

This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in Cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]

EIF3M Products (2)

mRNA	Protein	Name
NM_001307929.2	NP_001294858.1	eukaryotic translation initiation factor 3 subunit M isoform 2
NM_006360.6	NP_006351.2	eukaryotic translation initiation factor 3 subunit M isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	25849773	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3M Protein Structure

PCI

0
100
200
300
374 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 3 subunit M	B5 receptor

EIF3M Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EIF3M	Q7L2H7	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
Intra	EIF3M	Q7L2H7	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781
Intra	EIF3M	Q7L2H7	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	35271311
Cross	EIF3M	Q7L2H7	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034
Intra	EIF3M	Q7L2H7	EIF3H	Homo sapiens	O15372	Pull Down	23623729
Intra	EIF3M	Q7L2H7	EIF3H	Homo sapiens	O15372	Anti Tag CoIP	35271311
Intra	EIF3M	Q7L2H7	EIF3F	Homo sapiens	O00303	Y2H Prey Pooling	32296183
Intra	EIF3M	Q7L2H7	EIF3F	Homo sapiens	O00303	BiFC	25416956
Intra	EIF3M	Q7L2H7	EIF3F	Homo sapiens	O00303	Anti Tag CoIP	25416956
Intra	EIF3M	Q7L2H7	EIF3F	Homo sapiens	O00303	Y2H Array	32296183
Intra	EIF3M	Q7L2H7	EIF3F	Homo sapiens	O00303	Pull Down	23623729
Intra	EIF3M	Q7L2H7	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF3M Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71577	EIF3M Protein, Human (His-SUMO)	Q7L2H7-1 (S2-T374)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Colon Squamous Cell Carcinoma	Colonic Epidermoid Carcinoma Squamous Cell Carcinoma Of Colon Squamous Cell Carcinoma Of The Colon
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04269	EIF3M Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20918	Eif3m Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27435	Eif3m Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EIF3M	VGNC	VGNC:72095
Felis catus	EIF3M	VGNC	VGNC:61787
Rattus norvegicus	EIF3M	RGD	RGD:1565840
Mus musculus	EIF3M	MGD	MGI:1351744
Bos taurus	EIF3M	VGNC	VGNC:28403
Canis familiaris	EIF3M	VGNC	VGNC:40279
Others	EIF3M	NCBI