FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc)

FGFR-1 beta is a member of the FGFR family that interacts with fibroblast growth factors and regulates mitosis and differentiation. It specifically binds acidic and basic fibroblast growth factors and is involved in limb induction. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived FGFR-1 beta, expressed by HEK293 , with C-hFc labeled tag. FGFR-1 beta (IIIb) Protein, Human (HEK293, Fc), has molecular weight of 76-106 kDa.

The FGFR-1 beta protein is a highly conserved member of the fibroblast growth factor receptor (FGFR) family, sharing a similar amino acid sequence with other members. FGFR family members exhibit different affinities for ligands and are distributed across various tissues. The full-length protein consists of an extracellular region with three immunoglobulin-like domains, a hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, initiating downstream signals that regulate mitogenesis and differentiation. FGFR-1 beta specifically binds to both acidic and basic fibroblast growth factors and plays a role in limb induction. Mutations in this gene have been associated with several syndromes and disorders, including Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Various alternatively spliced variants encoding different protein isoforms have been identified, although not all variants have been fully characterized. The FGFR-1 beta protein exhibits ubiquitous expression in multiple tissues, including the ovary, fat, and 25 other tissues.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-hFc

P11362-14/NP_075594.1 (R22-K221&A270-E285)&AAB19502 (H1-P47)

2260  [NCBI]

76-106 kDa

≥ 95%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.