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FGG/Fibrinogen gamma chain Protein, Human (P.pastoris)

Cat. No.: HY-P75772
COA Handling Instructions

FGG/fibrinogen gamma chain proteins polymerize together with FGA and FGB to form the fibrin matrix, which is essential for blood clot formation. In addition to coagulation, it aids in early wound repair, stabilizes lesions, and guides cell migration. FGG/Fibrinogen gamma chain Protein, Human (P.pastoris) is the recombinant human-derived FGG/Fibrinogen gamma chain protein, expressed by P. pastoris , with tag free. The total length of FGG/Fibrinogen gamma chain Protein, Human (P.pastoris) is 285 a.a., with molecular weight of ~32.2 kDa.

For research use only. We do not sell to patients.

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Description

FGG/fibrinogen gamma chain proteins polymerize together with FGA and FGB to form the fibrin matrix, which is essential for blood clot formation. In addition to coagulation, it aids in early wound repair, stabilizes lesions, and guides cell migration. FGG/Fibrinogen gamma chain Protein, Human (P.pastoris) is the recombinant human-derived FGG/Fibrinogen gamma chain protein, expressed by P. pastoris , with tag free. The total length of FGG/Fibrinogen gamma chain Protein, Human (P.pastoris) is 285 a.a., with molecular weight of ~32.2 kDa.

Background

Fibrinogen gamma chain (FGG/Fibrinogen gamma chain) protein, in concert with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to create the insoluble fibrin matrix, a pivotal component in blood clot formation during hemostasis. Beyond its role in coagulation, this protein contributes to early wound repair by stabilizing lesions and guiding cell migration in re-epithelialization. Initially believed to be essential for platelet aggregation, subsequent studies revealed that it is not absolutely required for thrombus formation in vivo. FGG/Fibrinogen gamma chain enhances the expression of SELP in activated platelets via an ITGB3-dependent pathway. Essential for successful pregnancy, maternal fibrinogen plays a crucial role, and fibrin deposition is associated with infection, providing protection against IFNG-mediated hemorrhage. Furthermore, FGG/Fibrinogen gamma chain may facilitate the antibacterial immune response through both innate and T-cell mediated pathways. Structured as a heterohexamer with two sets of three non-identical chains (alpha, beta, and gamma), the protein's conformation places the N-termini in a small central domain.

Species

Human

Source

P. pastoris

Tag

Tag Free

Accession

P02679 (V169-L453)

Gene ID
Molecular Construction
N-term
FGG (V169-L453)
Accession # P02679
C-term
Synonyms
Fibrinogen gamma chain; FGG; PRO2061
Molecular Weight

Approximately 32.2 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Solution

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

FGG/Fibrinogen gamma chain Protein, Human (P.pastoris) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
FGG/Fibrinogen gamma chain Protein, Human (P.pastoris)
Cat. No.:
HY-P75772
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