FGG - fibrinogen gamma chain Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2266

About FGG

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:154,604,136-154,612,656 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues, 25 paralogues and is associated with 6 phenotypes. Restricted expression toward liver (RPKM 3614.5).

Summary

The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by Thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

FGG Products (2)

mRNA	Protein	Name
NM_000509.6	NP_000500.2	fibrinogen gamma chain isoform gamma-A precursor
NM_021870.3	NP_068656.2	fibrinogen gamma chain isoform gamma-B precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	7822297	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10788510	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	7822297	GOA
enables structural molecule activity	IDA IDA: Inferred from direct assay	8910396	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in blood coagulation, fibrin clot formation	IDA IDA: Inferred from direct assay	16846481	GOA
involved in blood coagulation, fibrin clot formation	IMP IMP: Inferred from mutant phenotype	11001902	GOA
involved in cell-matrix adhesion	IDA IDA: Inferred from direct assay	10903502	GOA
involved in fibrinolysis	IDA IDA: Inferred from direct assay	16846481	GOA
involved in negative regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	10903502	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	10903502	GOA
involved in plasminogen activation	IDA IDA: Inferred from direct assay	16846481	GOA
involved in platelet aggregation	IDA IDA: Inferred from direct assay	6281794	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	10903502	GOA
involved in positive regulation of exocytosis	IDA IDA: Inferred from direct assay	19193866	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IDA IDA: Inferred from direct assay	8100742	GOA
involved in positive regulation of peptide hormone secretion	IDA IDA: Inferred from direct assay	19193866	GOA
involved in positive regulation of protein secretion	IDA IDA: Inferred from direct assay	19193866	GOA
involved in positive regulation of vasoconstriction	IDA IDA: Inferred from direct assay	15739255	GOA
involved in protein polymerization	IMP IMP: Inferred from mutant phenotype	12706644	GOA
involved in protein secretion	IMP IMP: Inferred from mutant phenotype	18676163	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	8910396	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	6777381	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	6777381	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	6777381	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	6777381	GOA
part of fibrinogen complex	IDA IDA: Inferred from direct assay	6451630	GOA
located in platelet alpha granule	IDA IDA: Inferred from direct assay	6777381	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGG Protein Structure

Fib_alpha

Fibrinogen_C

0
100
200
300
400
453 a.a.

Protein Preferred Names	Protein Names
fibrinogen gamma chain	fibrinogen, gamma polypeptide

FGG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	FGG	P02679	gapA	Mycoplasma pneumoniae	P75358	Far-WB	21546586
Cross	FGG	P02679	gapA	Mycoplasma pneumoniae	P75358	ELISA	21546586

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FGG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75772	FGG/Fibrinogen gamma chain Protein, Human (P.pastoris)	P02679-1/NP_068656.2 (V169-L453)	≥ 95%, as determined by reducing SDS-PAGE.

FGG Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82151	Fibrinogen gamma Chain Antibody (YA1896)	WB, FC	Human
HY-P83925	Fibrinogen gamma Chain Antibody (YA3622)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P83925A	Fibrinogen gamma Chain Antibody (YA3622)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P85163	Fibrinogen gamma Chain Antibody (YA4855)	WB, IHC-P, FC	Human
HY-P85164	Fibrinogen gamma Chain Antibody (YA4856)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Afibrinogenemia, Congenital	Congenital Afibrinogenemia Afibrinogenemia Factor I Deficiency Familial Afibrinogenemia Hypofibrinogenemia, Congenital Fibrinogen Deficiency Afibrinogenemia Congenital CAFBN Congenital Hypofibrinogenemia Hypofibrinogenemia Complement Factor I Deficiency
Dysfibrinogenemia, Congenital	Dysfibrinogenemia Hypodysfibrinogenemia Familial Dysfibrinogenemia Familial Hypodysfibrinogenemia Hypodysfibrinogenemia, Congenital Dysfibrinogenemia, Familial Congenital Dysfibrinogenemia DYSFIBRIN
Hypofibrinogenemia, Familial	Familial Hypofibrinogenemia
Fibrinogen Deficiency, Congenital	Congenital Fibrinogen Deficiency
Thrombosis	Thrombosis Of Blood Vessel
Thrombophilia	Hypercoagulability State
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Femoral Vein Thrombophlebitis	Phlebitis And Thrombophlebitis Of Femoral Vein Thrombophlebitis Of The Femoral Vein Thrombophlebitis Of Deep Femoral Vein
Alopecia-Mental Retardation Syndrome 1	APMR1 Alopecia-Intellectual Disability Syndrome 1 Amr Syndrome Alopecia-Intellectual Disability Syndrome Amr Syndrome 1 Alopecia With Severe Intellectual Deficit Apmr Alopecia Intellectual Disbility Syndrome 1 Perniola-Krajewska-Carnevale Syndrome Alopecia - Intellectual Disability Syndrome Alopecia With Mental Retardation Syndrome 1 Perniola Krajewska Carnevale Syndrome
Gingival Recession	Localized Gingival Recession Gingival Recession, Localized Minimal Gingival Recession Moderate Gingival Recession Severe Gingival Recession Gingival Recession, Minimal Gingival Recession, Severe Atrophy Of Gums Gum Atrophy Gingival Atrophy
Intermediate Malignant Teratoma	Malignant Teratoma, Intermediate Intermediate Immature Teratoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04925	FGG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17794	Fgg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24262	Fgg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FGG	VGNC	VGNC:54208
Rattus norvegicus	FGG	RGD	RGD:2613
Mus musculus	FGG	MGD	MGI:95526
Felis catus	FGG	VGNC	VGNC:62261
Macaca mulatta	FGG	VGNC	VGNC:72656
Bos taurus	FGG	VGNC	VGNC:28990
Others	FGG	NCBI