Glycophorin C/GYPC Protein, Human (HEK293, His)

Glycophorin C (GYPC) protein is a minor sialoglycoprotein in human erythrocyte membranes whose extracellular domain may contain Gerbich antigen and Plasmodium falciparum merozoite receptors. In addition to blood group determinants, GYPC critically regulates erythrocyte stability, placing it at the crossroads of structural integrity and immune interactions. Glycophorin C/GYPC Protein, Human (HEK293, His) is the recombinant human-derived Glycophorin C/GYPC protein, expressed by HEK293 , with N-His labeled tag. The total length of Glycophorin C/GYPC Protein, Human (HEK293, His) is 57 a.a., with molecular weight of ~8.4 KDa.

Glycophorin C (GYPC) protein is a minor sialoglycoprotein found in human erythrocyte membranes. The extracellular domain of GYPC is the probable location for both the blood group Gerbich antigens and receptors utilized by Plasmodium falciparum merozoites. Beyond its involvement in blood group determinants, GYPC plays a crucial role in regulating the stability of red blood cells. This dual functionality positions GYPC at the intersection of structural integrity and immune interactions, underscoring its significance in maintaining erythrocyte stability and its potential involvement in modulating host interactions with the malaria parasite Plasmodium falciparum.

Human

HEK293

N-His

P04921 (M1-M57)

2995  [NCBI]

Approximately 8.4 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.