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  3. Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi)

Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi)

Cat. No.: HY-P700413
Handling Instructions

Growth Hormone R (GHR) is the receptor for pituitary growth hormone, crucial in postnatal body growth regulation. Binding to its ligand activates the JAK2/STAT5 pathway, facilitating intracellular signaling. The soluble form, GHBP (Growth Hormone Binding Protein), acts as a growth hormone reservoir in the bloodstream. GHBP may modulate or inhibit growth hormone signaling, contributing to intricate growth process regulation. Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived Growth Hormone R/GHR protein, expressed by HEK293, with C-Avi, C-mFc labeled tag. The total length of Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi) is 238 a.a., with molecular weight of 56.6 kDa.

For research use only. We do not sell to patients.

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Description

Growth Hormone R (GHR) is the receptor for pituitary growth hormone, crucial in postnatal body growth regulation. Binding to its ligand activates the JAK2/STAT5 pathway, facilitating intracellular signaling. The soluble form, GHBP (Growth Hormone Binding Protein), acts as a growth hormone reservoir in the bloodstream. GHBP may modulate or inhibit growth hormone signaling, contributing to intricate growth process regulation. Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi) is the recombinant human-derived Growth Hormone R/GHR protein, expressed by HEK293, with C-Avi, C-mFc labeled tag. The total length of Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi) is 238 a.a., with molecular weight of 56.6 kDa.

Background

Growth Hormone R (GHR) functions as the receptor for pituitary gland growth hormone, playing a pivotal role in the regulation of postnatal body growth. Upon binding to its ligand, GHR activates the JAK2/STAT5 pathway, facilitating the intracellular signaling cascade. Additionally, the soluble form of the receptor, known as GHBP (Growth Hormone Binding Protein), serves as a reservoir for growth hormone in the bloodstream. GHBP may also exert modulatory or inhibitory effects on growth hormone signaling, contributing to the intricate regulation of growth processes.

Species

Human

Source

HEK293

Tag

C-Avi;C-mFc

Accession

P10912 (A27-Y264)

Gene ID
Molecular Construction
N-term
GHR (A27-Y264)
Accession # P10912
mFc-Avi
C-term
Synonyms
Somatotropin receptor Serum-binding protein;
AA Sequence

AILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFY

Molecular Weight

56.6 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Growth Hormone R/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi)
Cat. No.:
HY-P700413
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