GHR - growth hormone receptor Gene

Also Known as GHBP; GHIP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2690

About GHR

Cytogenetic location: 5p13.1-p12 Genomic coordinates (GRCh38): 5:42,423,439-42,721,878 (from NCBI)

This gene has 13 transcripts (splice variants), 422 orthologues, 23 paralogues and is associated with 6 phenotypes. Biased expression in fat (RPKM 43.6), liver (RPKM 35.0) and 7 other tissues.

Summary

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

GHR Products (11)

mRNA	Protein	Name
NM_000163.5	NP_000154.1	growth hormone receptor isoform 1 precursor
NM_001242399.2	NP_001229328.1	growth hormone receptor isoform 2 precursor
NM_001242400.2	NP_001229329.1	growth hormone receptor isoform 1 precursor
NM_001242401.4	NP_001229330.1	growth hormone receptor isoform 1 precursor
NM_001242402.2	NP_001229331.1	growth hormone receptor isoform 1 precursor
NM_001242403.3	NP_001229332.1	growth hormone receptor isoform 1 precursor
NM_001242404.2	NP_001229333.1	growth hormone receptor isoform 1 precursor
NM_001242405.2	NP_001229334.1	growth hormone receptor isoform 1 precursor
NM_001242406.2	NP_001229335.1	growth hormone receptor isoform 1 precursor
NM_001242460.1	NP_001229389.1	growth hormone receptor isoform 3 precursor
NM_001242462.1	NP_001229391.1	growth hormone receptor isoform 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables growth factor binding	IPI IPI: Inferred from physical interaction	9360546	GOA
enables growth hormone receptor activity	IDA IDA: Inferred from direct assay	1549776	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16116438	GOA
enables lipid binding	EXP EXP: Inferred from Experiment	25846210	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	1549776	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8943276	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	1549776	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to hormone stimulus	IMP IMP: Inferred from mutant phenotype	7565946	GOA
involved in growth hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	1549776	GOA
involved in growth hormone receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	7565946	GOA
involved in hormone metabolic process	IMP IMP: Inferred from mutant phenotype	8137822	GOA
involved in insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	7565946	GOA
involved in positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	2813379	GOA
NOT involved in receptor internalization	IDA IDA: Inferred from direct assay	9360546	GOA
involved in receptor internalization	IDA IDA: Inferred from direct assay	9360546	GOA
NOT involved in response to cycloheximide	IDA IDA: Inferred from direct assay	9360546	GOA
involved in response to cycloheximide	IDA IDA: Inferred from direct assay	9360546	GOA
involved in response to estradiol	IDA IDA: Inferred from direct assay	12552091	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	8137822	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	8137822	GOA
located in extracellular space	IMP IMP: Inferred from mutant phenotype	2825030	GOA
part of growth hormone receptor complex	IDA IDA: Inferred from direct assay	1549776	GOA
located in membrane	IDA IDA: Inferred from direct assay	1549776	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	2825030	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	8137822	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	8137822	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GHR Protein Structure

EpoR_lig-bind

fn3

GHBP

0
100
200
300
400
500
600
638 a.a.

Protein Preferred Names	Protein Names
growth hormone receptor	GH receptor

GHR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GHR	P10912	PTPN3	Homo sapiens	P26045	Array	12907755
Intra	GHR	P10912	PTPN3	Homo sapiens	P26045	Phosphatase Assay	12907755
Intra	GHR	P10912	PTPN3	Homo sapiens	P26045	Far-WB	12907755
Intra	GHR	P10912	PTPRB	Homo sapiens	P23467	Array	12907755
Intra	GHR	P10912	PTPRB	Homo sapiens	P23467	Phosphatase Assay	12907755
Intra	GHR	P10912	PTPRB	Homo sapiens	P23467	Phosphatase Assay	19167335
Intra	GHR	P10912	PTPRH	Homo sapiens	Q9HD43	Array	12907755
Intra	GHR	P10912	PTPRH	Homo sapiens	Q9HD43	Phosphatase Assay	12907755
Intra	GHR	P10912	PTPRJ	Homo sapiens	Q12913	Phosphatase Assay	19167335
Intra	GHR	P10912	PTPN1	Homo sapiens	P18031	Far-WB	12907755
Intra	GHR	P10912	PTPN1	Homo sapiens	P18031	Array	12907755
Intra	GHR	P10912	PTPN2	Homo sapiens	P17706	Far-WB	12907755
Intra	GHR	P10912	PTPN2	Homo sapiens	P17706	Phosphatase Assay	12907755
Intra	GHR	P10912	PTPN2	Homo sapiens	P17706	Array	12907755
Intra	GHR	P10912	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	GHR	P10912	PTPN9	Homo sapiens	P43378	Phosphatase Assay	12907755
Intra	GHR	P10912	PTPN9	Homo sapiens	P43378	Array	12907755
Cross	GHR	P10912	Ncoa6	Rattus norvegicus	Q9JLI4	Pull Down	10866662

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GHR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72024	Growth Hormone Receptor/GHR Protein, Human (HEK293, hFc)	P10912-1 (A27-Y264)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72204	Growth Hormone Receptor/GHR Protein, Human (His-SUMO)	P10912-1 (F19-Y264)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78869	Growth Hormone Receptor/GHR Protein, Human (Biotinylated, HEK293, His)	P10912-1 (A27-Y264)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700413	Growth Hormone Receptor/GHR Protein, Human (Biotinylated, HEK293, mFc-Avi)	P10912-1 (A27-Y264)	≥ 95%, as determined by reducing SDS-PAGE.

GHR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810776	Growth hormone receptor Antibody (YA10019)	WB, ICC/IF, FC	Human, Mouse, Rat
HY-P81107	Growth hormone receptor Antibody	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Laron Syndrome	Growth Hormone Insensitivity Syndrome Growth Hormone Receptor Deficiency Laron Dwarfism Pituitary Dwarfism Ii Laron-Type Isolated Somatotropin Defect Primary Growth Hormone Resistance Laron-Type Dwarfism Laron Type Pituitary Dwarfism I Primary Growth Hormone Insensitivity Primary Gh Resistance Gh-R Deficiency Growth Hormone Receptor Defect Laron-Type Pituitary Dwarfism Laron-Type Short Stature Severe Gh Insensitivity Ghis Short Stature Due To A Defect In Growth Hormone Receptor Or Post-Receptor Pathway Complete Growth Hormone Insensitivity Gh Receptor Deficiency Primary Gh Insensitivity Short Stature Due To Growth Hormone Resistance LARS
Growth Hormone Insensitivity, Partial	Short Stature Due To Partial Ghr Deficiency GHIP Increased Responsiveness To Growth Hormone Short Stature Due To Partial Growth Hormone Receptor Deficiency Isolated Partial Growth Hormone Deficiency Partial Ighd Short Stature, Idiopathic, Autosomal
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Growth Hormone Deficiency, Isolated Partial	Short Stature Due To Growth Hormone Secretagogue Receptor Deficiency GHDP Short Stature Due To Ghsr Deficiency Ghrelin Receptor Deficiency Hormone, Growth, Deficiency, Isolated Partial Short Stature, Idiopathic, Autosomal
Specific Learning Disability	Specific Learning Difficulty Specific Learning Disorder
Acromegaly	Gigantism Growth Hormone Excess Pituitary Giant Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma
Insulin-Like Growth Factor I	Insulin-Like Growth Factor I Deficiency IGF1 DEFICIENCY Insulin-Like Growth Factor I, Resistance To Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency Growth Delay Due To Insulin-Like Growth Factor I Resistance IGF1RES Igf-I Resistance Somatomedin, End-Organ Insensitivity To Somatomedin-C Somatomedin-C, Resistance To Growth Retardation With Sensorineural Deafness And Mental Retardation Insulin-Like Growth Factor 1 Resistance To Igf-1 Resistance Somatomedin End-Organ Insensitivity To Somatomedin-C Resistance To Growth Restriction With Sensorineural Deafness And Intellectual Disability Growth Delay-Deafness-Intellectual Disability Syndrome Growth Delay-Hearing Loss-Intellectual Disability Syndrome Igf-1 Deficiency Primary Insulin-Like Growth Factor Deficiency Resistance To Igf-1 Insulin-Like Growth Factor 1 Resistance End-Organ Insensitivity To Somatomedin Igf1 Resistance Resistance To Insulin-Like Growth Factor I Resistance To Somatomedin-C Insulin-Like Growth Factor 1, Resistance To
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Turner Syndrome	Monosomy X Gonadal Dysgenesis Turner Type Ullrich-Turner Syndrome Bonnevie-Ullrich Syndrome Karyotype 45, X Genital Dwarfism, Turner Type Gonadal Dysgenesis 45,X Turner'S Syndrome Gonadal Dysgenesis - Turner Monosomy X Syndrome Xo Syndrome Genital Dwarfism 45, X Syndrome Bonnevie-Ulrich Syndrome Chromosome X Monosomy X Schereshevkii Turner Syndrome Turner Varny Syndrome Ts 45,X Syndrome 45,X/46,Xx Syndrome Turners Syndrome Gonadal Dysgenesis, 45,X X0 Syndrome
Uremia	Uremia Of Renal Origin
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Actinic Keratosis	Solar Keratosis Actinic Keratosis Senile Hyperkeratosis Sk - Solar Keratosis Keratosis, Actinic Seborrheic Keratosis Ak - [Actinic Keratosis] Sk - [Solar Keratosis]
Pituitary Adenoma	Adenoma Of The Pituitary Gland Pituitary Adenomas Adenoma, Pituitary Pituitary Gland Adenoma Pituitary Neoplasms
Hypopituitarism	Pituitary Hypofunction Pituitary Insufficiency Pituitary Hormone Deficiency Subpituitarism Hypophyseal Dystrophy Hypohypophysism Anterior Pituitary Insufficiency Deficient Secretion Of One Or More Pituitary Hormones Hypopituitarism Syndrome Pituitary Deficiency Pituitary Failure Pituitary Insufficiency Nos Anterior Pituitary Hypofunction Deficient Secretion Of All Pituitary Hormones Hypopituitary Dwarfism Hyposomatotropic Dwarfism Hypophyseal Dwarfism Hypopituitary Cachexia Hypophyseal Short Stature Panhypopituitarism Syndrome Pituitary Cachexia Juvenile Hypopituitarism Pituitary Dwarfism Pituitary Gland Hypofunction Primary Hypopituitarism Secondary Hypogonadism Prepubertal Panhypopituitarism Prepubertal Dwarfism Postpartum Panhypopituitary Syndrome Postpartum Hypopituitarism Pituitary Short Stature Pituitary Infantilism Pituitary Hypogonadism Pituitary Hypoadrenocorticism
Schizophrenia 11	Sczd11 Schizophrenia Susceptibility Locus, Chromosome 10q-Related
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Pituitary Hormone Deficiency, Combined, 2	Panhypopituitarism Combined Pituitary Hormone Deficiency CPHD2 Ateliotic Dwarfism With Hypogonadism Pituitary Dwarfism Iii Hanhart Dwarfism Simmond'S Disease Simmonds' Disease Cphd Pituitary Hormone Deficiency, Combined Hormone Deficiency, Pituitary, Combined, Type 2 Pituitary Dwarfism Type 3 Sheehan Syndrome
Hyperpituitarism
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Hyperinsulinism	Hyperinsulinemia
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Severe Combined Immunodeficiency, X-Linked	X-Linked Severe Combined Immunodeficiency SCIDX1 XSCID Scidx X-Linked Scid X-Scid Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative Scid, X-Linked Immunodeficiency 4 Imd4 Gamma Chain Deficiency Scid-X1 X-Linked Combined Immunodeficiency Diseases Thymic Epithelial Hypoplasia Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency Severe Combined Immunodeficiency T- B+, X-Linked Il2rg Scid, T- B+ Nk- T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency T-B+ Scid Due To Gamma Chain Deficiency T-B+ Severe Combined Immunodeficiency, X-Linked Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative Agammaglobulinemia Swiss Type Scid X-Linked Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Gestational Diabetes	Gestational Diabetes Mellitus GDM Diabetes Mellitus Arising In Pregnancy Maternal Gestational Diabetes Mellitus Diabetes Mellitus, Gestational Diabetes Mellitus, Pregnancy Related Diabetes, Pregnancy-Induced Diabetes Gestational Diabetes, Gestational Diabetes Of Pregnancy Gdm - [Gestational Diabetes Mellitus] Gestational Diabetes Mellitus Nos Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Obstructive Jaundice	Jaundice, Obstructive Cholestatic Jaundice Cholestatic Jaundice Syndrome Obstructive Hyperbilirubinemia Jaundice Obstructive Jaundice Cholestatic
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Scoliosis
Diabetes Mellitus	Diabetes
Spondylocostal Dysostosis 1, Autosomal Recessive	Jarcho-Levin Syndrome SCDO1 Vertebral Anomalies Spondylothoracic Dysplasia Costovertebral Dysplasia Spondylothoracic Dysostosis Spondylocostal Dysostosis 1 Autosomal Recessive Spondylocostal Dysostosis 1 Spondylocostal Dysostosis, Autosomal Recessive, 1 Doid:0112365 Dysostosis, Spondylocostal, Autosomal Recessive, Type 1
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Three M Syndrome 1	3-M Syndrome Yakut Short Stature Syndrome 3m Syndrome Le Merrer Syndrome Dolichospondylic Dysplasia Gloomy Face Syndrome Three M Syndrome 3M1 3m Syndrome 1 Miller-Mckusick-Malvaux Syndrome 3-Msbn Three-M Slender-Boned Nanism Miller-Mckusick-Malvaux-Syndrome 3-M Syndrome 1 3m Syndrome-1 3m Syndrome, Type 1 Dwarfism Dwarfism Tall Vertebrae
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-164419A	Atesidorsen sodium	Inhibitor	98.58%	Phase 2
HY-153485	Cimdelirsen	Inhibitor	/	Phase 2
HY-153485A	Cimdelirsen sodium	Inhibitor	/	Phase 2
HY-164419	Atesidorsen	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10283	S1H	Antagonist	99.32%	Unkown
HY-156373	MN714	Inhibitor	99.12%	Unkown
HY-159697	ISIS 532401		/	Unkown
HY-159697A	ISIS 532401 sodium		/	Unkown
HY-RS05412	GHR Human Pre-designed siRNA Set A		/	Unkown
HY-RS16936	Ghr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20741	Ghrl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23379	Ghr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GHR	MGD	MGI:95708
Macaca mulatta	GHR	VGNC	VGNC:72922
Rattus norvegicus	GHR	RGD	RGD:2687
Bos taurus	GHR	VGNC	VGNC:50184
Felis catus	GHR	VGNC	VGNC:62544
Canis familiaris	GHR	VGNC	VGNC:41206
Others	GHR	NCBI