PTPRB - protein tyrosine phosphatase receptor type B Gene

Also Known as PTPB; HPTPB; VEPTP; HPTP-BETA; R-PTP-BETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5787

About PTPRB

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,515,870-70,637,429 (from NCBI)

This gene has 11 transcripts (splice variants), 266 orthologues, 35 paralogues and is associated with 89 phenotypes. Broad expression in lung (RPKM 16.0), spleen (RPKM 13.5) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

PTPRB Products (5)

mRNA Protein Name
NM_001109754.4 NP_001103224.1 receptor-type tyrosine-protein phosphatase beta isoform a
NM_001206971.3 NP_001193900.1 receptor-type tyrosine-protein phosphatase beta isoform c precursor
NM_001206972.3 NP_001193901.1 receptor-type tyrosine-protein phosphatase beta isoform d precursor
NM_001330204.2 NP_001317133.1 receptor-type tyrosine-protein phosphatase beta isoform e
NM_002837.6 NP_002828.3 receptor-type tyrosine-protein phosphatase beta isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cadherin binding IPI
IPI: Inferred from physical interaction
28926625 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12840032 GOA
Biological Process GO Annotation Evidence References Source
involved in dephosphorylation IDA
IDA: Inferred from direct assay
19116766 GOA
involved in osteoblast differentiation IDA
IDA: Inferred from direct assay
22869525 GOA
Cellular Component GO Annotation Evidence References Source
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRB Protein Structure

fn3

fn3: Fibronectin type III domain (36 - 100)

fn3

fn3: Fibronectin type III domain (116 - 189)

fn3

fn3: Fibronectin type III domain (292 - 364)

fn3

fn3: Fibronectin type III domain (379 - 454)

fn3

fn3: Fibronectin type III domain (469 - 541)

fn3

fn3: Fibronectin type III domain (556 - 629)

fn3

fn3: Fibronectin type III domain (644 - 720)

fn3

fn3: Fibronectin type III domain (733 - 807)

fn3

fn3: Fibronectin type III domain (821 - 894)

fn3

fn3: Fibronectin type III domain (908 - 982)

fn3

fn3: Fibronectin type III domain (998 - 1072)

fn3

fn3: Fibronectin type III domain (1087 - 1160)

fn3

fn3: Fibronectin type III domain (1176 - 1248)

fn3

fn3: Fibronectin type III domain (1262 - 1342)

fn3

fn3: Fibronectin type III domain (1357 - 1431)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1727 - 1960)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1997 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase beta

  • VE-PTP

PTPRB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTPRB P23467 TEK Homo sapiens Q02763
Phosphatase Assay
19167335
Intra
PTPRB P23467 EGFR Homo sapiens P00533
Phosphatase Assay
19167335
Intra
PTPRB P23467 ERBB2 Homo sapiens P04626
Phosphatase Assay
19167335
Intra
PTPRB P23467 MAPK3 Homo sapiens P27361
Phosphatase Assay
19167335
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Generalized Epilepsy With Febrile Seizures Plus, Type 1

  • GEFSP1

  • GEFS+1

  • Generalized Epilepsy With Febrile Seizures Plus 1

  • Gefs+, Type 1

  • Generalised Epilepsy With Febrile Seizures Plus 1

  • Generalised Epilepsy With Febrile Seizures Plus Type 1

  • Generalized Epilepsy With Febrile Seizures Plus Type 1

  • Gefs+ Type 1

  • Epilepsy, Generalized, With Febrile Seizures Plus, Type 1
Skin Angiosarcoma

  • Angiosarcoma Of Skin

  • Hemangiosarcoma Of The Skin

  • Haemangiosarcoma Of Skin

  • Lymphangiosarcoma Of Skin

  • Cutaneous Angiosarcoma

  • Malignant Haemangioendothelioma Of Skin
Ovarian Angiosarcoma

  • Hemangiosarcoma Of Ovary
Diabetic Macular Edema
Liver Angiosarcoma

  • Angiosarcoma Of Liver

  • Angiosarcoma Of The Liver

  • Hemangiosarcoma Of The Liver

  • Primary Angiosarcoma Of Liver

  • Kupffer Cell Sarcoma Of Liver

  • Kupffer Cell Sarcoma Of Unspecified Site
Lymphangiosarcoma

  • Skin Lymphangiosarcoma

  • Stewart Treves Syndrome

  • Lymphangiosarcoma Of Stewart And Treves

  • Malignant Lymphangioendothelioma

  • Stewart-Treves Syndrome
Kuhnt-Junius Degeneration

  • Neovascular Age-Related Macular Degeneration

  • Exudative Senile Macular Degeneration Of Retina

  • Senile Macular Degeneration, Wet

  • Wet Senile Macular Retinal Degeneration

  • Exudative Age-Related Macular Degeneration

  • Exudative Macular Degeneration
Vascular Cancer

  • Blood Vessel Tumors

  • Malignant Vascular Neoplasm

  • Renal Vein Leiomyosarcoma

  • Vascular Neoplasms

  • Blood Vessel Neoplasm

  • Blood Vessel Tumor

  • Blood Vessel Tumour Disorder

  • Haemangiomatous Tumour

  • Leiomyosarcoma Of The Renal Vein

  • Malignant Great Vessel Tumor

  • Malignant Tumor Of Pulmonary Artery

  • Malignant Tumor Of Pulmonary Vein

  • Malignant Vascular Tumor

  • Neoplasm Of Great Vessel

  • Pulmonary Artery Malignant Neoplasm

  • Pulmonary Vein Malignant Neoplasm

  • Vascular Tissue Neoplasm

  • Vascular Tumors

  • Blood Vessel Cancer

  • Neoplasms, Vascular Tissue

  • Malignant Neoplasm Of Great Vessels
Generalized Epilepsy With Febrile Seizures Plus

  • Gefs+

  • Genetic Epilepsy With Febrile Seizures Plus

  • Generalized Epilepsy With Febrile Seizures-Plus

  • Genetic Epilepsy With Febrile Seizures-Plus

  • Epilepsy, Generalized, With Febrile Seizures Plus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11433 PTPRB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21705 Ptprb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28223 Ptprb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTPRB MGD MGI:97809
Macaca mulatta PTPRB VGNC VGNC:76611
Bos taurus PTPRB VGNC VGNC:33545
Rattus norvegicus PTPRB RGD RGD:1305922
Felis catus PTPRB VGNC VGNC:69169
Canis familiaris PTPRB VGNC VGNC:45183
Others PTPRB NCBI