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Atesidorsen sodium

(Synonyms: COR-004 sodium; ATL1103 sodium; ISIS 227452 sodium)
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Atesidorsen (COR-004, ATL1103) sodium is an antisense oligonucleotide targeting the growth hormone receptor (GHR). Atesidorsen sodium binds to GHR mRNA, inhibits human GHR translation, and reduces GHR synthesis through RNase H degradation. Atesidorsen sodium reduces hepatic GHR mRNA and serum IGF-I. Atesidorsen sodium can be used in research related to acromegaly.

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  • Reinheit : 98.58%
  • CAS. Nr.: 1826859-79-3
  • Molecular Weight:7164 (free acid)
  • Speicherung:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Atesidorsen sodium Chemical Structure
    Atesidorsen sodium Chemical Structure
CAS. Nr.: 1826859-79-3
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  • Atesidorsen sodium Chemical Structure
    Atesidorsen sodium Chemical Structure DNA, d(P-thio)([2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]rG-G-m5C-A-T-T-m5C-T-T-T-m5C-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC), sodium salt (1:19)
    1/16
  • DNA, d(P-thio)([2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]rG-G-m5C-A-T-T-m5C-T-T-T-m5C-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC), sodium salt (1:19)