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PTPRH - protein tyrosine phosphatase receptor type H Gene

Also Known as SAP1; R-PTP-H

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5794

About PTPRH

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,181,247-55,209,501 (from NCBI)

This gene has 7 transcripts (splice variants), 81 orthologues and 35 paralogues. Biased expression in small intestine (RPKM 32.9), duodenum (RPKM 31.2) and 7 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several Cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

PTPRH Products (2)

mRNA	Protein	Name
NM_001161440.3	NP_001154912.2	receptor-type tyrosine-protein phosphatase H isoform 2 precursor
NM_002842.5	NP_002833.4	receptor-type tyrosine-protein phosphatase H isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables cadherin binding	IPI IPI: Inferred from physical interaction	28926625	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12907755	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRH Protein Structure

fn3

Y_phosphatase

0
200
400
600
800
1000
1115 a.a.

Protein Preferred Names	Protein Names
receptor-type tyrosine-protein phosphatase H	stomach cancer-associated protein tyrosine phosphatase 1

PTPRH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPRH	Q9HD43	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	PTPRH	Q9HD43	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	PTPRH	Q9HD43	GHR	Homo sapiens	P10912	Array	12907755
Intra	PTPRH	Q9HD43	GHR	Homo sapiens	P10912	Far-WB	12907755
Intra	PTPRH	Q9HD43	EGFR	Homo sapiens	P00533	Anti Tag CoIP	28065597
Intra	PTPRH	Q9HD43	DHPS	Homo sapiens	P49366	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Peutz-Jeghers Syndrome	PJS Polyposis, Hamartomatous Intestinal Polyps-And-Spots Syndrome Lentiginosis, Perioral Periorificial Lentiginosis Syndrome Hamartomatous Intestinal Polyposis Hamartomatous Polyp Colonic Hamartomatous Polyp Gastric Peutz-Jeghers Polyp Peutz Jeghers Colon Polyp Peutz Jeghers Polyp Peutz-Jeghers Polyp Of Small Intestine Peutz-Jeghers Small Bowel Hamartoma Peutz Jeghers Polyposis Intestinal Polyposis-Cutaneous Pigmentation Syndrome Peutz-Jeghers Polyposis Polyposis, Intestinal, Ii Intestinal Hamartomatous Polyposis Peutz-Jeghers Polyp Peutz-Jeghers Polyp Of The Stomach Peutz Jehgers Polyp Peutz-Jeghers Polyps Of Small Bowel
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11440	PTPRH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTPRH	VGNC	VGNC:69174
Canis familiaris	PTPRH	VGNC	VGNC:45189
Macaca mulatta	PTPRH	VGNC	VGNC:76617
Mus musculus	PTPRH	MGD	MGI:3026877
Bos taurus	PTPRH	VGNC	VGNC:57057
Rattus norvegicus	PTPRH	RGD	RGD:620553
Others	PTPRH	NCBI