IFN-beta Protein, Rhesus (HEK293, Fc)

IFN-beta Protein is an immunomodulatory cytokine of the type 1 interferon family. IFN-beta Protein reduces joint inflammation by inhibiting the RANKL-c-Fos signaling pathway. IFN-beta Protein regulates mitochondrial fission through STAT5, PGAM5, and Drp1 to rescue neurodegeneration. IFN-beta Protein, Rhesus (HEK293, Fc) is the recombinant Rhesus Macaque-derived IFN-beta protein, expressed by HEK293 , with C-mFc labeled tag. The total length of IFN-beta Protein, Rhesus (HEK293, Fc) is 166 a.a., with molecular weight of ~46.4 kDa.

Interferon (IFN) constitutes a family of cytokines that naturally secrete immunoregulatory functions. They boost macrophages to destroy tumor cells, viruses and bacteria. There are two types of IFN: Type 1 includes IFN-α and β, and type 2 consists only of IFN-γ. IFN-beta and IFN-gamma have opposite effects, IFN-gamma promotes the inflammatory response, while IFN-beta is primarily anti-inflammatory. Exogenous IFN-beta reduces joint inflammation by inhibiting the RANKL-c-Fos signaling pathway. IFN-beta rescues neurodegeneration by regulating mitochondrial fission through STAT5, PGAM5, and Drp1^[1][2][3].

Rhesus Macaque

HEK293

C-mFc

EHH24077.1 (M22-N187)

/

Approximately 46.4 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.