2. Recombinant Proteins
  3. Cytokines and Growth Factors Receptor Proteins
  4. Interleukin & Receptors Cytokine Receptors
  5. IL-22BP
  6. IL-22BP/IL-22RA2 Protein, Human (HEK293, His-Fc)

IL-22BP/IL-22RA2 Protein, Human (HEK293, His-Fc)

Cat. No.: HY-P75855
Handling Instructions

IL-22BP/IL-22RA2 Protein, specifically Isoform 2, acts as an IL22 receptor and antagonist, inhibiting IL22 activity by preventing its interaction with the functional IL-22R complex in vitro. This regulatory role suggests its potential in modulating inflammatory responses. In contrast, Isoform 1 is involved in processes related to successful pregnancy, indicating a distinct role in reproductive physiology. The dual roles of IL-22BP isoforms highlight their versatility in influencing both inflammatory pathways and reproductive outcomes. IL-22BP/IL-22RA2 Protein, Human (HEK293, His-Fc) is the recombinant human-derived IL-22BP/IL-22RA2 protein, expressed by HEK293, with C-hFc, C-His labeled tag. The total length of IL-22BP/IL-22RA2 Protein, Human (HEK293, His-Fc) is 231 a.a., with molecular weight of 80-90 kDa.

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Description

IL-22BP/IL-22RA2 Protein, specifically Isoform 2, acts as an IL22 receptor and antagonist, inhibiting IL22 activity by preventing its interaction with the functional IL-22R complex in vitro. This regulatory role suggests its potential in modulating inflammatory responses. In contrast, Isoform 1 is involved in processes related to successful pregnancy, indicating a distinct role in reproductive physiology. The dual roles of IL-22BP isoforms highlight their versatility in influencing both inflammatory pathways and reproductive outcomes. IL-22BP/IL-22RA2 Protein, Human (HEK293, His-Fc) is the recombinant human-derived IL-22BP/IL-22RA2 protein, expressed by HEK293, with C-hFc, C-His labeled tag. The total length of IL-22BP/IL-22RA2 Protein, Human (HEK293, His-Fc) is 231 a.a., with molecular weight of 80-90 kDa.
Background

IL-22BP, specifically Isoform 2, serves as a receptor for IL22. This isoform not only binds to IL22 but also acts as an antagonist by preventing the interaction between IL22 and the functional IL-22R complex, consequently inhibiting the activity of IL22 in vitro. The regulatory function of Isoform 2 suggests its potential involvement in modulating inflammatory responses. On the other hand, Isoform 1 is implicated in processes related to establishing and maintaining successful pregnancy, indicating a distinct role in reproductive physiology. The dual roles of IL-22BP isoforms highlight their versatility in influencing both inflammatory pathways and reproductive outcomes.
Species

Human
Source

HEK293
Tag

C-hFc;C-His
Accession

Q969J5-2 (M1-P231)
Gene ID
Molecular Construction
N-term
IL-22BP (M1-P231)
Accession # Q969J5-2
hFc-His
C-term
Synonyms
Interleukin-22 receptor subunit alpha-2; IL-22RA2; CRF2-10; CRF2-S1; IL-22BP; ZcytoR16
Molecular Weight

80-90 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

IL-22BP/IL-22RA2 Protein, Human (HEK293, His-Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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