IL22RA2 - interleukin 22 receptor subunit alpha 2 Gene

Also Known as CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116379

About IL22RA2

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:137,143,820-137,173,644 (from NCBI)

This gene has 3 transcripts (splice variants), 131 orthologues and 11 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

IL22RA2 Products (3)

mRNA Protein Name
NM_052962.3 NP_443194.1 interleukin-22 receptor subunit alpha-2 isoform 1 precursor
NM_181309.2 NP_851826.1 interleukin-22 receptor subunit alpha-2 isoform 2 precursor
NM_181310.2 NP_851827.1 interleukin-22 receptor subunit alpha-2 isoform 3 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables interleukin-22 binding IDA
IDA: Inferred from direct assay
11390453 GOA
enables interleukin-22 receptor activity IDA
IDA: Inferred from direct assay
11390454 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL22RA2 Protein Structure

Tissue_fac

Tissue_fac: Tissue factor (7 - 146)

Interfer-bind

Interfer-bind: Interferon-alpha/beta receptor, fibronectin type III (158 - 262)

  • 0
  • 100
  • 200
  • 263 a.a.
Protein Preferred Names Protein Names

interleukin-22 receptor subunit alpha-2

  • cytokine receptor class-II member 10

Recombinant IL22RA2 Proteins

Cat. No. Product Name Accession Purity
HY-P72557 IL-22BP/IL-22RA2 Protein, Human (HEK293, His) Q969J5-2 (T22-P231) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75854 IL-22BP/IL-22RA2 Protein, Human (HEK293, Fc) Q969J5-1 (T22-P263) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75855 IL-22BP/IL-22RA2 Protein, Human (HEK293, His-Fc) Q969J5-2 (T22-P231) ≥ 90%, as determined by reducing SDS-PAGE.

IL22RA2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811000 IL-22RA2 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Multisystem Inflammatory Syndrome In Children

  • Mis-C

  • Multisystem Inflammatory Disorder In Children And Adolescents

  • Paediatric Inflammatory Multisystemic Syndrome

  • Mic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06738 IL22RA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174618 Human IL22RA2 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IL22RA2 VGNC VGNC:30145
Mus musculus IL22RA2 MGD MGI:2665114
Macaca mulatta IL22RA2 VGNC VGNC:73600
Felis catus IL22RA2 VGNC VGNC:62906
Rattus norvegicus IL22RA2 RGD RGD:1303169
Canis familiaris IL22RA2 VGNC VGNC:41971
Others IL22RA2 NCBI