KEL/Kelch-like protein 41 Protein, Human (HEK293, His)

KEL/Kelch-like protein 41 acts as a zinc endopeptidase with a distinct endothelin-3-converting enzyme function. It selectively cleaves endothelin-1 (EDN1), endothelin-2 (EDN2), and endothelin-3 (EDN3), displaying a preference for EDN3. KEL's endopeptidase activity plays a pivotal role in processing endothelin peptides, emphasizing its involvement in the modulation of endothelin signaling pathways. KEL/Kelch-like protein 41 Protein, Human (HEK293, His) is the recombinant human-derived KEL/Kelch-like protein 41 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of KEL/Kelch-like protein 41 Protein, Human (HEK293, His) is 665 a.a., with molecular weight of 85-120 kDa.

KEL/Kelch-like protein 41 functions as a zinc endopeptidase with specific endothelin-3-converting enzyme activity. It demonstrates the ability to cleave endothelin-1 (EDN1), endothelin-2 (EDN2), and endothelin-3 (EDN3), displaying a notable preference for EDN3 over the other substrates. Through its endopeptidase activity, KEL contributes to the processing of endothelin peptides, highlighting its role in the modulation of endothelin signaling pathways.

Human

HEK293

C-6*His

P23276 (N68-W732)

3792  [NCBI]

NFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW

85-120 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.