KEL - Kell metallo-endopeptidase (Kell blood group) Gene

Homo sapiens

Also known as ECE3; Kell; CD238

Gene ID: 3792 | Gene type: protein coding

About KEL

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:142,941,114-142,962,363 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 143 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 20.5), bone marrow (RPKM 20.3) and 2 other tissues.

Summary

This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the Neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]

KEL Products(1)

mRNA	Protein	Name
NM_000420.3	NP_000411.1	kell blood group glycoprotein

KEL Protein Structure

Peptidase_M13_N

Peptidase_M13

0
200
400
600
732 a.a.

Protein Preferred Names

Protein Names

kell blood group glycoprotein

Kell blood group, metallo-endopeptidase

Recombinant KEL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70324	KEL/Kelch-like protein 41 Protein, Human (HEK293, His)	P23276 (N68-W732)	≥95%
HY-P70324A	KEL/Kelch-like protein 41 Protein, Human (HEK293, C-His)	P23276 (N68-W732)	≥95%

Related Diseases

Diseases

Alias

Blood Group--Kell System

KEL	Blood Group--Kell-Cellano System
Blood Group, Kell	Kell Blood Group System
Kell Blood Group	Blood Group System, Kell

Mcleod Syndrome

Mcleod Neuroacanthocytosis Syndrome	MLS
X-Linked Mcleod Syndrome	Mcleod Phenotype
Neuroacanthocytosis, Mcleod Type	Mcleod Syndrome With Or Without Chronic Granulomatous Disease
MCLDS	Mcleod Type Neuroacanthocytosis
Mcleod Syndrome With Chronic Granulomatous Disease	Neuroacanthocytosis Mcleod Type
Blood Group Deletion Syndrome

Neuroacanthocytosis

Neuroacanthocytosis Syndrome

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Blood Group Incompatibility

Fetal Erythroblastosis

Erythroblastosis, Fetal	Ef - Erythroblastosis Foetalis
Erythroblastosis Fetalis	Haemolytic Disease Due To Rhesus Isoimmunisation
Rhesus Isoimmunisation Of The Newborn

Neonatal Anemia

Anemia Neonatal	Anemia, Neonatal
Anaemia Neonatal	Neonatal Anaemia

Choreoacanthocytosis

Chorea-Acanthocytosis	CHAC
Acanthocytosis With Neurologic Disorder	Levine-Critchley Syndrome
Choreaacanthocytosis	Chorea Acanthocytosis
Neuroacanthocytosis	Levine-Critchley Syndrome, Formerly
Neuroacanthocytosis, Formerly	Choreo-Acanthocytosis
Acanthocytosis Chorea	Chorea Acanthocytosis Syndrome

Granulomatous Disease, Chronic, X-Linked

CGDX	Chronic Granulomatous Disease, X-Linked
X-Linked Chronic Granulomatous Disease	Cgd
Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked	Cdgx
X-Linked Chronic Cytochrome B-Negative Granulomatous Disease	Chronic Granulomatous Disease Cytochrome B-Negative X-Linked
Chronic Granulomatous Disease Cytochrome B-Positive X-Linked	Granulomatous Disease, Chronic, X-Linked, Variant

Lingual-Facial-Buccal Dyskinesia

Orofacial Dyskinesia	Oro-Facial Dyskinesia
Dyskinesias

Beta-Thalassemia Major

Cooley'S Anemia	Cooley Anemia
Mediterranean Anemia

Hemoglobinopathy

Hemoglobinopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139039	BSJ-4-116	Inhibitor	98.73%	Unkown
HY-145765	JQAD1		98.70%	Unkown
HY-123919	TL13-112	Inhibitor	98.15%	Unkown
HY-122582	TL13-12	Inhibitor	98.06%	Unkown
HY-155962	Tubulin polymerization-IN-47	Inhibitor	99.51%	Unkown
HY-155963	Tubulin polymerization-IN-48	Inhibitor	/	Unkown
HY-158062	LC-1-40		/	Unkown
HY-RS07233	KEL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KEL	RGD	RGD:1565470
Canis familiaris	KEL	VGNC	VGNC:42333
Bos taurus	KEL	VGNC	VGNC:30538
Macaca mulatta	KEL	VGNC	VGNC:81628
Mus musculus	KEL	MGD	MGI:1346053
Felis catus	KEL	VGNC	VGNC:80604
Others	KEL	NCBI

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