Tubulin polymerization-IN-48
Tubulin polymerization-IN-48 (Compound 4k) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-48 has a moderate effect on disruption of the microtubule network. Tubulin polymerization-IN-48 inhibits neuroblastoma cancer cell proliferation, with IC50s of 79 and 165 nM for Chp-134 and Kelly cell line.
For research use only. We do not sell to patients.
- CAS No.: 2982893-22-9
- Formula: C20H15Cl2N3O
- Molecular Weight:384.26
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHP-134 | GI50 |
0.079 μM
Compound: 4k
|
Growth inhibition of MYCN-amplified human CHP-134 cells assessed as reduction in cell viability measured after 3 days by Celltiter-glo assay
Growth inhibition of MYCN-amplified human CHP-134 cells assessed as reduction in cell viability measured after 3 days by Celltiter-glo assay
|
[PMID: 37736192] |
| Kelly | GI50 |
0.165 μM
Compound: 4k
|
Growth inhibition of MYCN-amplified human Kelly cells assessed as reduction in cell viability measured after 3 days by Celltiter-glo assay
Growth inhibition of MYCN-amplified human Kelly cells assessed as reduction in cell viability measured after 3 days by Celltiter-glo assay
|
[PMID: 37736192] |
Chemical Information
-
CAS No. 2982893-22-9
-
Molecular Weight 384.26
-
Formula C20H15Cl2N3O
-
SMILES
CC1=CC=C(C2=CN3C(C(C4=CC(Cl)=C(OC)C(Cl)=C4)=NC=C3)=N2)C=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)