1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Oxidoreductases (EC 1)
  4. L-xylulose reductase/DCXR Protein, Human (His)

L-xylulose reductase/DCXR Protein, Human (His)

Cat. No.: HY-P70082
COA Handling Instructions

L-xylulose reductase, encoded by the DCXR gene, plays a vital role in cellular metabolism by catalyzing the NADPH-dependent reduction of various pentoses, tetoses, trisaccharides, α-dicarbonyl compounds, and L-xylulose role. This enzyme is actively involved in the uronic acid cycle of glucose metabolism. L-xylulose reductase/DCXR Protein, Human (His) is the recombinant human-derived L-xylulose reductase/DCXR protein, expressed by E. coli , with N-6*His labeled tag. The total length of L-xylulose reductase/DCXR Protein, Human (His) is 244 a.a., with molecular weight of ~28.0 kDa.

For research use only. We do not sell to patients.

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5 μg $47 In-stock
10 μg $80 In-stock
50 μg $225 In-stock
100 μg $380 In-stock
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Description

L-xylulose reductase, encoded by the DCXR gene, plays a vital role in cellular metabolism by catalyzing the NADPH-dependent reduction of various pentoses, tetoses, trisaccharides, α-dicarbonyl compounds, and L-xylulose role. This enzyme is actively involved in the uronic acid cycle of glucose metabolism. L-xylulose reductase/DCXR Protein, Human (His) is the recombinant human-derived L-xylulose reductase/DCXR protein, expressed by E. coli , with N-6*His labeled tag. The total length of L-xylulose reductase/DCXR Protein, Human (His) is 244 a.a., with molecular weight of ~28.0 kDa.

Background

L-xylulose reductase, encoded by the DCXR gene, is a versatile enzyme that catalyzes the NADPH-dependent reduction of various pentoses, tetroses, trioses, alpha-dicarbonyl compounds, and specifically L-xylulose. As part of the uronate cycle in glucose metabolism, this enzyme participates in diverse biochemical reactions, contributing to the cellular processing of different sugars. Notably, L-xylulose reductase is implicated in water absorption and cellular osmoregulation in the proximal renal tubules. By producing xylitol, an osmolyte, this enzyme helps prevent osmolytic stress within the renal tubules, showcasing its potential role in maintaining cellular homeostasis in the kidney. The multifunctionality of L-xylulose reductase underscores its significance in both sugar metabolism and cellular osmoregulation, providing insights into its broader physiological impact.

Biological Activity

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Species

Human

Source

E. coli

Tag

N-6*His

Accession

Q7Z4W1 (M1-C244)

Gene ID
Molecular Construction
N-term
6*His
DCXR (M1-C244)
Accession # Q7Z4W1
C-term
Synonyms
rHuL-xylulose reductase/DCXR, His; L-Xylulose Reductase; XR; Carbonyl Reductase II; Dicarbonyl/L-Xylulose Reductase; Kidney Dicarbonyl Reductase; kiDCR; Sperm Surface Protein P34H; DCXR
AA Sequence

MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWAC

Molecular Weight

Approximately 28.0 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE

Appearance

Solution.

Formulation

Supplied as a 0.2 μm filtered solution of 50 mM Tris, 300 mM NaCl, 30% Glycerol, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

L-xylulose reductase/DCXR Protein, Human (His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
L-xylulose reductase/DCXR Protein, Human (His)
Cat. No.:
HY-P70082
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