L-xylulose reductase/DCXR Protein, Human (His)
L-xylulose reductase, encoded by the DCXR gene, plays a vital role in cellular metabolism by catalyzing the NADPH-dependent reduction of various pentoses, tetoses, trisaccharides, α-dicarbonyl compounds, and L-xylulose role. This enzyme is actively involved in the uronic acid cycle of glucose metabolism. L-xylulose reductase/DCXR Protein, Human (His) is the recombinant human-derived L-xylulose reductase/DCXR protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
L-xylulose reductase, encoded by the DCXR gene, plays a vital role in cellular metabolism by catalyzing the NADPH-dependent reduction of various pentoses, tetoses, trisaccharides, α-dicarbonyl compounds, and L-xylulose role. This enzyme is actively involved in the uronic acid cycle of glucose metabolism. L-xylulose reductase/DCXR Protein, Human (His) is the recombinant human-derived L-xylulose reductase/DCXR protein, expressed by E. coli , with N-6*His labeled tag.
Background
L-xylulose reductase, encoded by the DCXR gene, is a versatile enzyme that catalyzes the NADPH-dependent reduction of various pentoses, tetroses, trioses, alpha-dicarbonyl compounds, and specifically L-xylulose. As part of the uronate cycle in glucose metabolism, this enzyme participates in diverse biochemical reactions, contributing to the cellular processing of different sugars. Notably, L-xylulose reductase is implicated in water absorption and cellular osmoregulation in the proximal renal tubules. By producing xylitol, an osmolyte, this enzyme helps prevent osmolytic stress within the renal tubules, showcasing its potential role in maintaining cellular homeostasis in the kidney. The multifunctionality of L-xylulose reductase underscores its significance in both sugar metabolism and cellular osmoregulation, providing insights into its broader physiological impact.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
Q7Z4W1 (M1-C244)
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Molecular Construction
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N-term
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6*His
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DCXR (M1-C244)
Accession # Q7Z4W1 -
C-term
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Protein Length
Full Length
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Synonyms
DCXR; Short Chain Dehydrogenase/Reductase Family 20C Member 1; Dicarbonyl And L-Xylulose Reductase; Human Carbonyl Reductase 2; Dicarbonyl/L-Xylulose Reductase; XR; SDR20C1; Short Chain Dehydrogenase/Reductase Family 20C, Member 1; Kidney Dicarbonyl Reduc
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AA Sequence
MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWAC
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Molecular Weight
Approximately 29 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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