DCXR - dicarbonyl and L-xylulose reductase Gene

Homo sapiens

Also known as XR; DCR; HCR2; P34H; HCRII; KIDCR; PNTSU; SDR20C1

Gene ID: 51181 | Gene type: protein coding

About DCXR

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,035,858-82,037,697 (from NCBI)

This gene has 21 transcripts (splice variants), 186 orthologues and is associated with 2 phenotypes. Biased expression in liver (RPKM 345.1), kidney (RPKM 158.4) and 7 other tissues.

Summary

The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]

DCXR Products(2)

mRNA	Protein	Name
NM_001195218.1	NP_001182147.1	L-xylulose reductase isoform 2
NM_016286.4	NP_057370.1	L-xylulose reductase isoform 1

DCXR Protein Structure

adh_short_C2

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

L-xylulose reductase

carbonyl reductase 2

Recombinant DCXR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70082	L-xylulose reductase/DCXR Protein, Human (His)	Q7Z4W1 (M1-C244)	≥95%

Related Diseases

Diseases

Alias

Pentosuria

Xylitol Dehydrogenase Deficiency	L-Xylulosuria
L-Xylulose Reductase Deficiency	Essential Pentosuria
PNTSU	Essential Benign Pentosuria

Erythrasma

Infection Due To Corynebacterium Minutissimum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03602	DCXR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DCXR	MGD	MGI:1915130
Canis familiaris	DCXR	VGNC	VGNC:39825
Felis catus	DCXR	VGNC	VGNC:98907
Rattus norvegicus	DCXR	RGD	RGD:620031
Macaca mulatta	DCXR	VGNC	VGNC:71669
Others	DCXR	NCBI