DCXR - dicarbonyl and L-xylulose reductase Gene

Also Known as XR; DCR; HCR2; P34H; HCRII; KIDCR; PNTSU; SDR20C1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51181

About DCXR

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,035,858-82,037,697 (from NCBI)

This gene has 21 transcripts (splice variants), 186 orthologues and is associated with 2 phenotypes. Biased expression in liver (RPKM 345.1), kidney (RPKM 158.4) and 7 other tissues.

Summary

The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]

DCXR Products (2)

mRNA	Protein	Name
NM_001195218.1	NP_001182147.1	L-xylulose reductase isoform 2
NM_016286.4	NP_057370.1	L-xylulose reductase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-xylulose reductase (NADPH) activity	IDA IDA: Inferred from direct assay	11882650	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA IDA: Inferred from direct assay	19442656	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in glucose metabolic process	IDA IDA: Inferred from direct assay	11882650	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19442656	GOA
involved in xylulose metabolic process	IDA IDA: Inferred from direct assay	11882650	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	23264731	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCXR Protein Structure

adh_short_C2

0
100
200
244 a.a.

Protein Preferred Names	Protein Names
L-xylulose reductase	carbonyl reductase 2

DCXR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCXR	Q7Z4W1	DCXR	Homo sapiens	Q7Z4W1	Y2H Array	31515488
Intra	DCXR	Q7Z4W1	DCXR	Homo sapiens	Q7Z4W1	Validated Y2H	32296183
Intra	DCXR	Q7Z4W1	GLRX2	Homo sapiens	Q9NS18	Validated Y2H	32296183
Intra	DCXR	Q7Z4W1	DCXR	Homo sapiens	Q7Z4W1	Y2H Array	25416956
Intra	DCXR	Q7Z4W1	BLTP3B	Homo sapiens	A0JNW5	Anti Tag CoIP	33961781
Intra	DCXR	Q7Z4W1	TRIM5	Homo sapiens	Q9C035	Anti Tag CoIP	33961781
Intra	DCXR	Q7Z4W1	DCXR	Homo sapiens	Q7Z4W1	Y2H Array	32296183
Intra	DCXR	Q7Z4W1	DCXR	Homo sapiens	Q7Z4W1	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DCXR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70082	L-xylulose reductase/DCXR Protein, Human (His)	Q7Z4W1 (M1-C244)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Pentosuria	Xylitol Dehydrogenase Deficiency L-Xylulosuria L-Xylulose Reductase Deficiency Essential Pentosuria PNTSU Essential Benign Pentosuria
Erythrasma	Infection Due To Corynebacterium Minutissimum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03602	DCXR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18348	Dcxr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24827	Dcxr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DCXR	MGD	MGI:1915130
Canis familiaris	DCXR	VGNC	VGNC:39825
Felis catus	DCXR	VGNC	VGNC:98907
Rattus norvegicus	DCXR	RGD	RGD:620031
Macaca mulatta	DCXR	VGNC	VGNC:71669
Others	DCXR	NCBI