MZB1/PERP1 Protein, Human (HEK293, Fc)

The MZB1/PERP1 Protein associates with IgM heavy and light chains, aiding IgM assembly and secretion. It functions as a molecular chaperone or oxidoreductase, exhibiting low oxidoreductase activity. Isoform 2 potentially regulates apoptosis. MZB1/PERP1 oversees Ca(2+) stores, antibody secretion, and integrin activation, diversifying peripheral B-cell functions. As a hormone-regulated adipokine and pro-inflammatory cytokine, it contributes to chronic inflammation, affecting cellular expansion and insulin response in adipocytes. MZB1/PERP1 may also play a role in insulin resistance onset. MZB1/PERP1 Protein, Human (HEK293, Fc) is the recombinant human-derived MZB1/PERP1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of MZB1/PERP1 Protein, Human (HEK293, Fc) is 185 a.a., with molecular weight of ~44.9 KDa.

The MZB1/PERP1 Protein associates with immunoglobulin M (IgM) heavy and light chains, facilitating the assembly and secretion of IgM. Its influence may stem from its role as a molecular chaperone or an oxidoreductase, given its demonstrated low level of oxidoreductase activity (By similarity). Isoform 2 potentially participates in the regulation of apoptosis. Moreover, MZB1/PERP1 contributes to the diversification of peripheral B-cell functions by overseeing Ca(2+) stores, antibody secretion, and integrin activation. Acting as a hormone-regulated adipokine and pro-inflammatory cytokine, it is implicated in chronic inflammation, influencing cellular expansion and blunting insulin response in adipocytes. Additionally, MZB1/PERP1 may play a role in the onset of insulin resistance.

Human

HEK293

C-hFc

Q8WU39 (M1-T185)

51237  [NCBI]

Approximately 44.9 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.