MZB1 - marginal zone B and B1 cell specific protein Gene

Also Known as PACAP; pERp1; MEDA-7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51237

About MZB1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,387,467-139,389,913 (from NCBI)

This gene has 8 transcripts (splice variants) and 102 orthologues. Biased expression in lymph node (RPKM 68.4), urinary bladder (RPKM 65.2) and 13 other tissues.

Summary

Involved in positive regulation of cell population proliferation. Located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

MZB1 Products (1)

mRNA Protein Name
NM_016459.4 NP_057543.2 marginal zone B- and B1-cell-specific protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11350957 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
21688198 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11350957 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
21688198 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MZB1 Protein Structure

DUF3456

DUF3456: TLR4 regulator and MIR-interacting MSAP (49 - 178)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

marginal zone B- and B1-cell-specific protein

  • HSPC190

MZB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MZB1 Q8WU39 TSG101 Homo sapiens Q99816
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MZB1 Proteins

Cat. No. Product Name Accession Purity
HY-P77094 MZB1/PERP1 Protein, Human (HEK293, Fc) Q8WU39-1 (D23-T185) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77095 MZB1/PERP1 Protein, Human (HEK293, His) Q8WU39-1 (D23-T185) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Mooren'S Ulcer

  • Mooren Ulcer

  • Moorens Ulcer
Isolated Growth Hormone Deficiency

  • Congenital Ighd

  • Congenital Isolated Gh Deficiency

  • Congenital Isolated Growth Hormone Deficiency

  • Non-Acquired Isolated Growth Hormone Deficiency

  • Pituitary Dwarfism

  • Dwarfism, Pituitary

  • Isolated Somatotropin Deficiency

  • Isolated Congenital Growth Hormone Deficiency

  • Familial Isolated Growth Hormone Deficiency

  • Ighd

  • Dwarfism, Growth Hormone Deficiency

  • Growth Hormone Deficiency Dwarfism

  • Isolated Gh Deficiency

  • Isolated Hgh Deficiency

  • Isolated Human Growth Hormone Deficiency

  • Isolated Somatotropin Deficiency Disorder

  • Dwarfism Pituitary
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Chromosome 22q11.2 Deletion Syndrome, Distal

  • 22q11.2 Deletion Syndrome

  • Autosomal Dominant Opitz G/Bbb Syndrome

  • Catch22

  • Cayler Cardiofacial Syndrome

  • Conotruncal Anomaly Face Syndrome

  • Digeorge Syndrome

  • Sedlackova Syndrome

  • Shprintzen Syndrome

  • Velocardiofacial Syndrome

  • 22q11.2 Distal Deletion Syndrome

  • Distal 22q11.2 Microdeletion Syndrome

  • 22q11.2ds

  • Vcfs

  • Velo-Cardio-Facial Syndrome

  • Distal Chromosome 22q11.2 Deletion Syndrome

  • Chromosome 22q11.2 Deletion Syndrome Distal

  • Chromosome 22q11.2 Deletion Syndrome

  • Deletion 22q11.2 Syndrome

  • 22q11ds

  • Catch 22

  • Digeorge Sequence

  • Microdeletion 22q11.2

  • Monosomy 22q11

  • Takao Syndrome

  • Distal Del(22)(Q11.2)

  • Distal Monosomy 22q11.2

  • Catch 22 Syndrome

  • Chromosome Deletion Syndrome 22q11.2, Distal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08976 MZB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19148 Mzb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25639 Mzb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MZB1 VGNC VGNC:43593
Felis catus MZB1 VGNC VGNC:63699
Mus musculus MZB1 MGD MGI:1917066
Rattus norvegicus MZB1 RGD RGD:1310251
Bos taurus MZB1 VGNC VGNC:31849
Macaca mulatta MZB1 VGNC VGNC:110450
Others MZB1 NCBI