NRG1-beta 2 Protein, Human (HEK293, Fc)

NRG1-beta 2 is an important membrane glycoprotein that mediates intercellular signaling and affects the growth and development of organ systems. This gene produces multiple isoforms (types I-VI) with tissue-specific expression. NRG1-beta 2 Protein, Human (HEK293, Fc) is the recombinant human-derived NRG1-beta 2 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of NRG1-beta 2 Protein, Human (HEK293, Fc) is 61 a.a., with molecular weight of ~35.5 kDa.

NRG1-beta 2, a membrane glycoprotein, serves as a crucial mediator of cell-cell signaling and plays a pivotal role in the growth and development of various organ systems. The gene encoding NRG1-beta 2 generates an exceptional diversity of isoforms through alternative promoter usage and splicing, with distinct tissue-specific expression patterns. These isoforms, categorized as types I, II, III, IV, V, and VI, exhibit significant structural variations. Dysregulation of the NRG1-beta 2 gene has been implicated in various diseases, including cancer, schizophrenia, and bipolar disorder (BPD). The broad expression of NRG1-beta 2 is evident in diverse tissues such as the thyroid, urinary bladder, and 19 other tissues. Understanding the multifaceted functions and regulatory mechanisms of NRG1-beta 2 isoforms is crucial for unraveling their roles in physiological processes and disease pathogenesis.

Human

HEK293

N-hFc

NP_001153480 (S177-Q237)

3084  [NCBI]

Approximately 35.5 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.