Neuroligin-3/NLGN3 Protein, Human (HEK293, His)

Neuroligin-3 (NLGN3) Protein, a cell surface protein, engages in cell-cell interactions by interacting with neurexin family members. It influences synapse function and signal transmission, potentially by clustering synaptic proteins. NLGN3 may facilitate initial synapse formation but is not indispensable for it. Additionally, it may participate in glia-glia or glia-neuron interactions during peripheral nervous system development. NLGN3 forms homodimers and heterodimers with NLGN1 and NLGN2, and interacts with neurexins and DLG4/PSD-95. Neuroligin-3/NLGN3 Protein, Human (HEK293, His) is the recombinant human-derived Neuroligin-3/NLGN3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuroligin-3/NLGN3 Protein, Human (HEK293, His) is 652 a.a., with molecular weight of 100-110 KDa.

Neuroligin-3 (NLGN3) is a cell surface protein that plays a crucial role in cell-cell interactions through its interactions with neurexin family members. It is involved in synapse function and synaptic signal transmission, potentially by clustering other synaptic proteins. While NLGN3 may promote the initial formation of synapses, it is not essential for this process. Additionally, it may be involved in glia-glia or glia-neuron interactions in the developing peripheral nervous system. NLGN3 forms homodimers and heterodimers with NLGN1 and NLGN2, and interacts with neurexins NRXN1, NRXN2, and NRXN3, with the interaction being mediated by heparan sulfate glycan modification on neurexin. Furthermore, NLGN3 interacts with DLG4/PSD-95 through its C-terminus, specifically with the PDZ domain 3 of DLG4/PSD-95.

Human

HEK293

C-His

Q9NZ94-2 (Q38-S689)

54413  [NCBI]

MWLRLGPPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAQGSWNGDQDAGPLLVENPRDYSTELS

100-110 kDa.

Greater than 90% as determined by reducing SDS-PAGE

Solution.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.