NLGN3 - neuroligin 3 Gene

Also Known as HNL3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54413

About NLGN3

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,144,841-71,175,307 (from NCBI)

This gene has 21 transcripts (splice variants), 245 orthologues, 13 paralogues and is associated with 5 phenotypes. Biased expression in brain (RPKM 14.8), adrenal (RPKM 2.6) and 4 other tissues.

Summary

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]

NLGN3 Products (4)

mRNA	Protein	Name
NM_001166660.2	NP_001160132.1	neuroligin-3 isoform 3 precursor
NM_001321276.2	NP_001308205.1	neuroligin-3 isoform 4
NM_018977.4	NP_061850.2	neuroligin-3 isoform 2 precursor
NM_181303.2	NP_851820.1	neuroligin-3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17292328	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	17292328	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adult behavior	IMP IMP: Inferred from mutant phenotype	12669065	GOA
involved in learning	IMP IMP: Inferred from mutant phenotype	12669065	GOA
involved in social behavior	IMP IMP: Inferred from mutant phenotype	12669065	GOA
involved in synapse organization	IMP IMP: Inferred from mutant phenotype	15150161	GOA
involved in vocalization behavior	IMP IMP: Inferred from mutant phenotype	12669065	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	15150161	GOA
located in excitatory synapse	IDA IDA: Inferred from direct assay	15620359	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLGN3 Protein Structure

COesterase

0
200
400
600
800
848 a.a.

Protein Preferred Names	Protein Names
neuroligin-3	gliotactin homolog

Recombinant NLGN3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76510	Neuroligin-3/NLGN3 Protein, Human (HEK293, His, solution)	Q9NZ94-2 (Q38-S689)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Autism X-Linked 1	Autism, Susceptibility To, X-Linked 1 AUTSX1 Autism Susceptibility, X-Linked 1 Autism, X-Linked 1 Autism, Susceptibility To, X-Linked, Type 1
Asperger Syndrome, X-Linked 1	Asperger Syndrome, X-Linked, Susceptibility To, 1 ASPGX1 Asperger Syndrome Susceptibility, X-Linked 1 Asperger Syndrome, X-Linked, 1 Asperger Syndrome X-Linked 1
Asperger Syndrome	Asperger Disorder Asperger Syndrome, Susceptibility To
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Childhood Disintegrative Disease	Childhood Disintegrative Disorder Disintegrative Psychosis Heller'S Syndrome Symbiotic Psychosis Dementia Infantilis Heller Syndrome Shared Paranoid Disorder
Pitt-Hopkins-Like Syndrome 1	Cortical Dysplasia-Focal Epilepsy Syndrome CDFES PTHSL1 Cdfe Syndrome Pitt-Hopkins Like Syndrome 1 Pitt-Hopkins-Like Syndrome-1 Cntnap2-Related Developmental And Epileptic Encephalopathy Cntnap2-Related Dee Mesh D006985 Mesh D008607
Atypical Autism	Pdd
Phelan-Mcdermid Syndrome	Chromosome 22q13.3 Deletion Syndrome 22q13.3 Deletion Syndrome Telomeric 22q13 Monosomy Syndrome PHMDS Deletion 22q13 Syndrome 22q13.3 Deletion Deletion 22q13.3 Syndrome Monosomy 22q13 Monosomy 22q13.3 22q13 Deletion Syndrome Monosomy 22q13 Syndrome 22q13 Deletion Chromosome Deletion
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Echolalia
Valproate Embryopathy	Fetal Valproate Syndrome Fetal Valproic Acid Syndrome Fvs Valproic Acid Embryopathy Fetal Valproate Spectrum Disorder Valproate Embryopathy, Susceptibility To Foetal Valproate Syndrome Foetal Valproic Acid Syndrome Susceptibility To Valproate Embryopathy Valproic Acid Antenatal Infection
Gene Duplication Disease	Gene Duplication Syndrome
Tic Disorder	Tics Behavioral Tic
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Potocki-Lupski Syndrome	PTLS Chromosome 17p11.2 Duplication Syndrome 17p11.2 Microduplication Syndrome Duplication 17p11.2 Syndrome Trisomy 17p11.2 Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2)) 17p11.2 Duplication Syndrome Dup(17)(P11.2p11.2) Pls Chromosome 17, Trisomy 17p11 2
Specific Language Impairment	Language Impairment, Specific
Stereotypic Movement Disorder	Stereotypy Habit Disorder Stereotyped Repetitive Movements Stereotyped Disorder Stereotypes Nos Stereotype Habit Disorder
Speech Disorder	Speech Disorders
Specific Developmental Disorder
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09341	NLGN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18397	Nlgn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24879	Nlgn3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NLGN3	RGD	RGD:621119
Mus musculus	NLGN3	MGD	MGI:2444609
Bos taurus	NLGN3	VGNC	VGNC:32110
Canis familiaris	NLGN3	VGNC	VGNC:43840
Felis catus	NLGN3	VGNC	VGNC:63823
Others	NLGN3	NCBI