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  6. OCIL/CLEC2D Protein, Human (Biotinylated, HEK293, Fc-Avi)

OCIL/CLEC2D Protein, Human (Biotinylated, HEK293, Fc-Avi)

Cat. No.: HY-P77902
Handling Instructions

The OCIL/CLEC2D protein acts as a receptor for KLRB1 and protects target cells from natural killer cell-mediated lysis. It not only inhibits osteoclast formation and bone resorption, but also regulates the release of interferon-γ, indicating that it has immune and bone-related regulatory functions. OCIL/CLEC2D Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived OCIL/CLEC2D protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag. The total length of OCIL/CLEC2D Protein, Human (Biotinylated, HEK293, Fc-Avi) is 132 a.a., with molecular weight of 68-75 kDa.

For research use only. We do not sell to patients.

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Description

The OCIL/CLEC2D protein acts as a receptor for KLRB1 and protects target cells from natural killer cell-mediated lysis. It not only inhibits osteoclast formation and bone resorption, but also regulates the release of interferon-γ, indicating that it has immune and bone-related regulatory functions. OCIL/CLEC2D Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived OCIL/CLEC2D protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag. The total length of OCIL/CLEC2D Protein, Human (Biotinylated, HEK293, Fc-Avi) is 132 a.a., with molecular weight of 68-75 kDa.

Background

OCIL/CLEC2D Protein serves as a receptor for KLRB1, providing protection to target cells against natural killer cell-mediated lysis. Not only does it inhibit osteoclast formation and bone resorption, but it also modulates the release of interferon-gamma, showcasing its regulatory role in immune responses and bone-related processes. Furthermore, OCIL/CLEC2D exhibits the ability to bind high molecular weight sulfated glycosaminoglycans, suggesting its involvement in interactions with extracellular components. Structurally, it exists as a homodimer with disulfide linkages, emphasizing the significance of its oligomeric form in mediating cellular functions associated with immune protection and bone homeostasis.

Species

Human

Source

HEK293

Tag

N-hFc;N-Avi

Accession

Q9UHP7 (R60-V191)

Gene ID
Molecular Construction
N-term
hFc-Avi
CLEC2D (R60-V191)
Accession # Q9UHP7
C-term
Synonyms
LLT-1; CLAX; LLT1; OCIL; CLEC2D; CLAXLLT-1; OCILmember D
Molecular Weight

68-75 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
OCIL/CLEC2D Protein, Human (Biotinylated, HEK293, Fc-Avi)
Cat. No.:
HY-P77902
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