PNLIPRP1 Protein, Dog (P.pastoris, His)

The PNLIPRP1 protein acts as an inhibitor of dietary triglyceride digestion and lacks lipase activity on various substrates. This regulatory effect suggests an effect on the breakdown of dietary triglycerides. PNLIPRP1 Protein, Dog (P.pastoris, His) is the recombinant dog-derived PNLIPRP1 protein, expressed by P. pastoris , with N-His labeled tag. The total length of PNLIPRP1 Protein, Dog (P.pastoris, His) is 450 a.a., with molecular weight of ~51.7 kDa.

The PNLIPRP1 protein appears to function as an inhibitor of dietary triglyceride digestion, as it lacks detectable lipase activity towards various substrates including triglycerides, diglycerides, phosphatidylcholine, galactolipids, or cholesterol esters in vitro. This suggests that PNLIPRP1 may play a regulatory role in the digestive process, potentially influencing the breakdown of dietary triglycerides. The absence of detectable lipase activity toward a range of substrates underscores its specificity as an inhibitor and hints at its involvement in the fine-tuning of lipid metabolism. A deeper investigation into the molecular mechanisms underlying PNLIPRP1's inhibitory function on dietary triglyceride digestion could provide valuable insights into its role in lipid metabolism regulation and its potential impact on overall digestive processes.

Dog

P. pastoris

N-His

P06857 (18K-467C)

404010  [NCBI]

KEVCYEQIGCFSDAEPWAGTAIRPLKVLPWSPERIGTRFLLYTNKNPNNFQTLLPSDPSTIEASNFQTDKKTRFIIHGFIDKGEENWLLDMCKNMFKVEEVNCICVDWKKGSQTSYTQAANNVRVVGAQVAQMLSMLSANYSYSPSQVQLIGHSLGAHVAGEAGSRTPGLGRITGLDPVEASFQGTPEEVRLDPTDADFVDVIHTDAAPLIPFLGFGTSQQMGHLDFFPNGGEEMPGCKKNALSQIVDLDGIWEGTRDFVACNHLRSYKYYSESILNPDGFASYPCASYRAFESNKCFPCPDQGCPQMGHYADKFAVKTSDETQKYFLNTGDSSNFARWRYGVSITLSGKRATGQAKVALFGSKGNTHQFNIFKGILKPGSTHSNEFDAKLDVGTIEKVKFLWNNNVVNPTFPKVGAAKITVQKGEEKTVHSFCSESTVREDVLLTLTPC

Approximately 51.7 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.