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Semaphorin-4C/SEMA4C Protein, Mouse (HEK293, Fc)

Cat. No.: HY-P71285
Handling Instructions

Semaphorin-4C/SEMA4C is the cell surface receptor of PLXNB2 and is critical for intercellular signaling. Semaphorin-4C/SEMA4C Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Semaphorin-4C/SEMA4C protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Semaphorin-4C/SEMA4C Protein, Mouse (HEK293, Fc) is 644 a.a., with molecular weight of 115-125 kDa.

For research use only. We do not sell to patients.

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Description

Semaphorin-4C/SEMA4C is the cell surface receptor of PLXNB2 and is critical for intercellular signaling. Semaphorin-4C/SEMA4C Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Semaphorin-4C/SEMA4C protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Semaphorin-4C/SEMA4C Protein, Mouse (HEK293, Fc) is 644 a.a., with molecular weight of 115-125 kDa.
Background

Semaphorin-4C (SEMA4C) acts as a cell surface receptor for PLXNB2, serving a crucial role in cell-cell signaling. The binding of SEMA4C to PLXNB2 initiates downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. This protein is essential for normal brain development, axon guidance, and cell migration. Additionally, SEMA4C is a likely signaling receptor that may contribute to myogenic differentiation through the activation of the stress-activated MAPK cascade. Notably, it engages in interactions with GIPC via its PDZ-binding motif and PDZ domain, as well as with NCDN and DLG4. The multifaceted functions of SEMA4C underscore its significance in coordinating various cellular processes.
Species

Mouse
Source

HEK293
Tag

C-hFc
Accession

Q64151 (A21-G664）
Gene ID

20353  [NCBI]
Molecular Construction
N-term
SEMA4C (A21-G664）
Accession # Q64151
hFc
C-term
Synonyms
Semaphorin-4C; Semaphorin I; S4c; Semacl1; Semai; Sema I; Semaphorin-C-like 1; M-Sema F; Sema4c
AA Sequence

AEMWWNLVPRKTVSSGELVTVVRRFSQTGIQDFLTLTLTEHSGLLYVGAREALFAFSVEALELQGAISWEAPAEKKIECTQKGKSNQTECFNFIRFLQPYNSSHLYVCGTYAFQPKCTYINMLTFTLDRAEFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRYMGTHHSIKTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKWTTFLKARLVCSAPDWKVYFNQLKAVHTLRGASWHNTTFFGVFQARWGDMDLSAVCEYQLEQIQQVFEGPYKEYSEQAQKWARYTDPVPSPRPGSCINNWHRDNGYTSSLELPDNTLNFIKKHPLMEDQVKPRLGRPLLVKKNTNFTHVVADRVPGLDGATYTVLFIGTGDGWLLKAVSLGPWIHMVEELQVFDQEPVESLVLSQSKKVLFAGSRSQLVQLSLADCTKYRFCVDCVLARDPYCAWNVNTSRCVATTSGRSGSFLVQHVANLDTSKMCNQYGIKKVRSIPKNITVVSGTDLVLPCHLSSNLAHAHWTFGSQDLPAEQPGSFLYDTGLQALVVMAAQSRHSGPYRCYSEEQGTRLAAESYLVAVVAGSSVTLEARAPLENLG

Molecular Weight

115-125 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

Semaphorin-4C/SEMA4C Protein, Mouse (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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