Sema4c - sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C Gene

Also Known as Semaf; Semai; sema I; Semacl1; M-Sema F

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20353

Summary

This gene encodes a member of the semaphorin family of proteins that have diverse functions in neuronal development, heart morphogenesis, vascular growth, tumor progression and immune cell regulation. Lack of the encoded protein in some mice causes exencephaly resulting in neonatal lethality. Mice that bypass exencephaly show no obvious behavioral defects but display distinct pigmentation defects. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Sema4c Products (6)

mRNA Protein Name
NM_001126047.3 NP_001119519.1 semaphorin-4C precursor
NM_001304329.1 NP_001291258.1 semaphorin-4C precursor
NM_001304330.1 NP_001291259.1 semaphorin-4C precursor
NM_001126047.3 NP_001119519.1 semaphorin-4C precursor
NM_001304329.1 NP_001291258.1 semaphorin-4C precursor
NM_001304330.1 NP_001291259.1 semaphorin-4C precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10318831 MGI
Biological Process GO Annotation Evidence References Source
involved in cell migration in hindbrain IMP
IMP: Inferred from mutant phenotype
21122816 MGI
involved in cerebellum development IMP
IMP: Inferred from mutant phenotype
21122816 MGI
involved in muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
15811348 MGI
involved in neural tube closure IMP
IMP: Inferred from mutant phenotype
21122816 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
31444474 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
31444474 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
21122816 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11134026 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
11134026 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
31444474 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
11134026 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
11134026 MGI
is active in postsynaptic density membrane IEP
IEP: Inferred from expression pattern
11134026 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
11134026 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

semaphorin-4C

  • semaphorin I

  • semaphorin-C-like 1

Recombinant Sema4c Proteins

Cat. No. Product Name Accession Purity
HY-P71285 Semaphorin-4C/SEMA4C Protein, Mouse (HEK293, Fc) Q64151 (A21-G664） ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12659 SEMA4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19073 Sema4c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25563 Sema4c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sema4c NCBI NCBI:54910