Somatostatin R1/SSR1 Protein, Human (HEK293, Fc)

The somatostatin R1 (SSR1) protein contains TRAP-α, TRAP-β, TRAP-δ, and TRAP-gamma, forming a heterotetramer. They play a role in binding calcium to the ER membrane and regulating the retention of ER-resident proteins. Somatostatin R1/SSR1 Protein, Human (HEK293, Fc) is the recombinant human-derived Somatostatin R1/SSR1 protein, expressed by HEK293 , with C-hFc labeled tag.

Somatostatin R1 (SSR1) is a protein involved in the regulation of endoplasmic reticulum (ER) membrane functions through its association with TRAP proteins. These TRAP proteins function within a complex dedicated to binding calcium to the ER membrane, thereby modulating the retention of resident ER proteins. SSR1 may play a role in the recycling of the translocation apparatus following the completion of the translocation process. Alternatively, it could serve as a membrane-bound chaperone, facilitating the folding of translocated proteins. The heterotetramer of TRAP proteins, composed of TRAP-alpha, TRAP-beta, TRAP-delta, and TRAP-gamma, interacts with palmitoylated calnexin (CALX), and this interaction is essential for the efficient folding of glycosylated proteins.

Human

HEK293

C-hFc

P43307-1/NP_003135.2 (V19-T207)

6745  [NCBI]

Lumenal Domain

VLFRGGPRGLLAVAQDLTEDEETVEDSIIEDEDDEAEVEEDEPTDLVEDKEEEDVSGEPEASPSADTTILFVKGEDFPANNIVKFLVGFTNKGTEDFIVESLDASFRYPQDYQFYIQNFTALPLNTVVPPQRQATFEYSFIPAEPMGGRPFGLVINLNYKDLNGNVFQDAVFNQTVTVIEREDGLDGET

Approximately 55-75 kDa, based on SDS-PAGE under reducing conditions.

• 
  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. /biology-dictionary/mcf7-cell.html  [Content Brief]